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CATH Superfamily 1.10.8.400

Enoyl acyl carrier protein reductase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Enoyl acyl carrier protein reductase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Enoyl acyl carrier protein reductase

The human malaria parasite Plasmodium falciparum synthesises fatty acids using a type II pathway that is absent in humans. The final step in fatty acid elongation is catalysed by enoyl acyl carrier protein reductase, a validated antimicrobial drug target. The final reaction in the FAS-II pathway is catalysed by the enoyl acyl carrier protein reductase enzyme (PfENR in P. falciparum, also known as PfFabI), which mediates the NADH-dependent reduction of trans-2-enoyl-ACP (acyl carrier protein) to acyl-ACP.

This superfamily entry represents the enoyl acyl carrier protein reductase-like domains.

DOI:10.1074/jbc.M112000200,DOI:10.1074/jbc.M701813200, PFAM:PF13561

GO Diversity

Unique GO annotations
15 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
4720 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 12
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC: 2
Unique GO: 15
Taxonomy
Unique Species: 4720