The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Haem peroxidase domain superfamily, animal type
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Dual oxidase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 A0A494BAW1 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 A2AQ92 (/IPI) Q9NRD8 (/IPI) Q9NRD9 (/IPI)
NAD(P)H oxidase activity GO:0016174
Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
3 A0A494BAW1 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
NAD(P)H oxidase activity GO:0016174
Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
2 Q9MZF4 (/NAS) Q9NRD9 (/NAS)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
2 Q9MZF4 (/NAS) Q9NRD9 (/NAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9NRD8 (/IDA)
NAD(P)H oxidase activity GO:0016174
Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
1 Q9NRD8 (/IDA)
NAD(P)H oxidase activity GO:0016174
Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
1 Q9NRD8 (/IMP)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
8 Q4S1D3 (/ISS) Q8CIY2 (/ISS) Q8HZK2 (/ISS) Q8HZK3 (/ISS) Q9ES45 (/ISS) Q9MZF4 (/ISS) Q9NRD8 (/ISS) Q9NRD9 (/ISS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
7 Q4S1D3 (/ISS) Q8CIY2 (/ISS) Q8HZK2 (/ISS) Q8HZK3 (/ISS) Q9ES45 (/ISS) Q9MZF4 (/ISS) Q9NRD8 (/ISS)
Cuticle development GO:0042335
The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
7 Q4S1D3 (/ISS) Q8CIY2 (/ISS) Q8HZK2 (/ISS) Q8HZK3 (/ISS) Q9ES45 (/ISS) Q9MZF4 (/ISS) Q9NRD8 (/ISS)
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
4 A0A2R8QJC5 (/IMP) A0A2R8RLY1 (/IMP) F1QVF2 (/IMP) Q08JS2 (/IMP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
4 A0A2R8QJC5 (/IMP) A0A2R8RLY1 (/IMP) F1QVF2 (/IMP) Q08JS2 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
4 A0A2R8QJC5 (/IMP) A0A2R8RLY1 (/IMP) F1QVF2 (/IMP) Q08JS2 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
4 A0A2R8QJC5 (/IMP) A0A2R8RLY1 (/IMP) F1QVF2 (/IMP) Q08JS2 (/IMP)
Macrophage chemotaxis GO:0048246
The movement of a macrophage in response to an external stimulus.
4 A0A2R8QJC5 (/IMP) A0A2R8RLY1 (/IMP) F1QVF2 (/IMP) Q08JS2 (/IMP)
Hydrogen peroxide biosynthetic process GO:0050665
The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
4 A0A2R8QJC5 (/IMP) A0A2R8RLY1 (/IMP) F1QVF2 (/IMP) Q08JS2 (/IMP)
Hydrogen peroxide biosynthetic process GO:0050665
The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
4 A0A2R8QJC5 (/IMP) A0A2R8RLY1 (/IMP) F1QVF2 (/IMP) Q08JS2 (/IMP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Thyroid hormone generation GO:0006590
The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
3 Q9ES45 (/TAS) Q9NRD8 (/TAS) Q9NRD9 (/TAS)
Fertilization GO:0009566
The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
3 A0A494BAW1 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Thyroid gland development GO:0030878
The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Thyroid hormone metabolic process GO:0042403
The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Hormone metabolic process GO:0042445
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Superoxide anion generation GO:0042554
The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
3 A0A494BAW1 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Adenohypophysis morphogenesis GO:0048855
The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
3 A0A494BAW1 (/IMP) A2AQ99 (/IMP) B7ZWM4 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
3 Q8HZK2 (/TAS) Q9NRD8 (/TAS) Q9NRD9 (/TAS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q9NRD8 (/IDA) Q9NRD9 (/IDA)
Superoxide anion generation GO:0042554
The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
2 Q9MZF4 (/NAS) Q9NRD9 (/NAS)
Hydrogen peroxide biosynthetic process GO:0050665
The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
2 Q9NRD8 (/IGI) Q9NRD9 (/IGI)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
2 Q9NRD8 (/IDA) Q9NRD9 (/IDA)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
2 Q9NRD8 (/IGI) Q9NRD9 (/IGI)
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
2 Q9NRD8 (/IGI) Q9NRD9 (/IGI)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q9NRD8 (/IDA)
Cuticle development GO:0042335
The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
1 Q9NRD9 (/IMP)
Cuticle development GO:0042335
The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
1 A2AQ92 (/ISO)
Superoxide anion generation GO:0042554
The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
1 Q9NRD8 (/IGI)
Hydrogen peroxide biosynthetic process GO:0050665
The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
1 Q9NRD9 (/NAS)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
1 A2AQ92 (/IGI)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 Q8CIY2 (/ISS) Q8HZK2 (/ISS) Q8HZK3 (/ISS) Q9ES45 (/ISS) Q9MZF4 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 Q8CIY2 (/ISS) Q8HZK2 (/ISS) Q8HZK3 (/ISS) Q9ES45 (/ISS) Q9MZF4 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
4 A0A494BAW1 (/ISO) A2AQ92 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 A0A494BAW1 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 A2AQ92 (/IDA) Q9NRD8 (/IDA) Q9NRD9 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
3 A0A494BAW1 (/ISO) A2AQ99 (/ISO) B7ZWM4 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q9NRD8 (/IDA) Q9NRD9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8HZK2 (/ISS) Q9ES45 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9NRD8 (/TAS) Q9NRD9 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9NRD8 (/IGI) Q9NRD9 (/IGI)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q9MZF4 (/NAS) Q9NRD9 (/NAS)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
2 Q9NRD8 (/IGI) Q9NRD9 (/IGI)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
2 Q8HZK2 (/ISS) Q9ES45 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9NRD8 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9NRD8 (/IGI)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q9NRD8 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9NRD8 (/HDA)