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CATH Superfamily 1.10.640.10

Haem peroxidase domain superfamily, animal type

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Haem peroxidase domain superfamily, animal type
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Dual oxidase 2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NAD(P)H oxidase (H(2)O(2)-forming). [EC: 1.6.3.1]
NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
  • When calcium is present, this transmembrane glycoprotein generates H(2)O(2) by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen.
  • The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups.
  • This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H(2)O(2) for the thyroid peroxidase-catalyzed biosynthesis of thyroid hormones.
 7 Q8CIY2 Q8HZK2 Q8HZK3 Q9ES45 Q9MZF4 Q9NRD8 Q9NRD9