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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: cytochrome P450 4F22 isoform X2

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Unspecific monooxygenase. [EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
 18 A0A0A0MR49 A0A0A0MR49 P13584 P15128 P15129 P24464 P33274 P51869 P51870 P51871
(8 more...)
Leukotriene-B(4) 20-monooxygenase. [EC: 1.14.14.94]
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH--hemoprotein reductase] + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH- -hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein found in mammals.
  • Formerly EC 1.14.13.30.
 8 A0A024R7J8 A0A024R7J8 P78329 Q08477 Q08477 Q3MID2 Q99N16 Q9EP75
Long-chain fatty acid omega-monooxygenase. [EC: 1.14.14.80]
A long-chain fatty acid + [reduced NADPH--hemoprotein reductase] + O(2) = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme thiolate) enzyme.
  • The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1).
  • The plant enzyme CYP86A1 also acts on laurate (12:0).
  • The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C(16) to C(20) saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position.
  • The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).
  • Formerly EC 1.14.13.205.
 7 O35728 O88833 P08516 P20816 P20817 Q02928 Q5TCH4
Docosahexaenoic acid omega-hydroxylase. [EC: 1.14.14.79]
Docosahexaenoate + [reduced NADPH--hemoprotein reductase] + O(2) = 22-hydroxydocosahexaenoate + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein isolated from human eye tissue.
  • Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy.
  • The enzyme also produces some 21-hydroxydocosahexaenoate.
  • Acts in a similar way on icosapentaenoic acid.
  • Formerly EC 1.14.13.199.
 4 A0A024R7J8 A0A024R7J8 Q08477 Q08477
Phylloquinone omega-hydroxylase. [EC: 1.14.14.78]
Phylloquinone + [reduced NADPH--hemoprotein reductase] + O(2) = omega- hydroxyphylloquinone + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein isolated from human tissue.
  • The enzyme will also act on menaquinone-4.
  • Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid.
  • CYP4F2 also oxidizes leukotriene B(4); see EC 1.14.13.30.
  • Formerly EC 1.14.13.194.
 2 P78329 Q9HBI6
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