The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vanillyl-alcohol Oxidase; Chain A, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: D-lactate dehydrogenase mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 31 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
D-lactate dehydrogenase (cytochrome) activity GO:0004458
Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
10 P39976 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) Q94AX4 (/IDA) Q94AX4 (/IDA)
(R)-2-hydroxyglutarate dehydrogenase activity GO:0051990
Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
10 O23240 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P84850 (/IDA) P84850 (/IDA)
(R)-2-hydroxyglutarate dehydrogenase activity GO:0051990
Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
8 O46096 (/IMP) Q7K511 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
8 P39976 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
7 P46681 (/IMP) P46681 (/IMP) P46681 (/IMP) P46681 (/IMP) P46681 (/IMP) P46681 (/IMP) P46681 (/IMP)
D-lactate dehydrogenase (cytochrome) activity GO:0004458
Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
6 P32891 (/IMP) P32891 (/IMP) P32891 (/IMP) P32891 (/IMP) P32891 (/IMP) P32891 (/IMP)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
4 Q9KKW5 (/ISS) Q9KKW5 (/ISS) Q9KKW5 (/ISS) Q9KKW5 (/ISS)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
4 O29853 (/IDA) O96759 (/IDA) Q94AX4 (/IDA) Q94AX4 (/IDA)
Alkylglycerone-phosphate synthase activity GO:0008609
Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.
3 O96759 (/IDA) Q585R0 (/IDA) Q585R0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 O96759 (/IPI) Q94AX4 (/IPI) Q94AX4 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q7TNG8 (/IPI) Q86WU2 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q94AX4 (/IDA) Q94AX4 (/IDA)
D-lactate dehydrogenase activity GO:0008720
Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
2 Q94AX4 (/IMP) Q94AX4 (/IMP)
D-lactate dehydrogenase activity GO:0008720
Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.
2 Q7TNG8 (/NAS) Q9D635 (/NAS)
Glycolate oxidase activity GO:0008891
Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide.
2 Q94AX4 (/IGI) Q94AX4 (/IGI)
Glycolate dehydrogenase activity GO:0019154
Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate.
2 Q94AX4 (/IDA) Q94AX4 (/IDA)
(R)-2-hydroxyglutarate dehydrogenase activity GO:0051990
Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
2 Q8CIM3 (/ISS) Q8N465 (/ISS)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
2 O96759 (/ISS) O97157 (/ISS)
D-lactate dehydrogenase (cytochrome) activity GO:0004458
Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
1 Q9C1X2 (/ISO)
D-lactate dehydrogenase (cytochrome) activity GO:0004458
Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
1 Q55BQ4 (/ISS)
Alkylglycerone-phosphate synthase activity GO:0008609
Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.
1 Q7YWB6 (/EXP)
Alkylglycerone-phosphate synthase activity GO:0008609
Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.
1 O97157 (/ISS)
Alcohol binding GO:0043178
Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group.
1 O96759 (/IDA)
2-hydroxyglutarate dehydrogenase activity GO:0047545
Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
1 O23240 (/IDA)
2-hydroxyglutarate dehydrogenase activity GO:0047545
Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
1 O23240 (/IMP)
D-2-hydroxy-acid dehydrogenase activity GO:0047809
Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate.
1 O29853 (/IDA)
(R)-2-hydroxyglutarate dehydrogenase activity GO:0051990
Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
1 Q8N465 (/EXP)
(R)-2-hydroxyglutarate dehydrogenase activity GO:0051990
Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
1 Q8CIM3 (/ISO)
(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity GO:0099615
Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor.
1 P39976 (/IDA)
(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity GO:0099615
Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor.
1 P39976 (/IMP)
(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity GO:0099615
Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor.
1 Q9C1X2 (/ISO)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lactate catabolic process GO:1903457
The chemical reactions and pathways resulting in the breakdown of lactate.
13 P32891 (/IMP) P32891 (/IMP) P32891 (/IMP) P32891 (/IMP) P32891 (/IMP) P32891 (/IMP) P46681 (/IMP) P46681 (/IMP) P46681 (/IMP) P46681 (/IMP)
(3 more)
L-serine biosynthetic process GO:0006564
The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
6 Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP) Q9I6H4 (/IMP)
Ether lipid biosynthetic process GO:0008611
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
4 O96759 (/IDA) Q585R0 (/IDA) Q585R0 (/IDA) Q7YWB6 (/IDA)
ATP biosynthetic process GO:0006754
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q7TNG8 (/NAS) Q9D635 (/NAS)
Ether lipid biosynthetic process GO:0008611
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
2 Q585R0 (/IMP) Q585R0 (/IMP)
Response to manganese ion GO:0010042
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
2 P84850 (/IDA) P84850 (/IDA)
Response to manganese ion GO:0010042
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
2 Q8CIM3 (/ISS) Q8N465 (/ISS)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
2 P84850 (/IDA) P84850 (/IDA)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
2 Q8CIM3 (/ISS) Q8N465 (/ISS)
Response to cobalt ion GO:0032025
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
2 P84850 (/IDA) P84850 (/IDA)
Response to cobalt ion GO:0032025
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
2 Q8CIM3 (/ISS) Q8N465 (/ISS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
2 P84850 (/IDA) P84850 (/IDA)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
2 Q8CIM3 (/ISS) Q8N465 (/ISS)
Methylglyoxal catabolic process GO:0051596
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
2 Q94AX4 (/IMP) Q94AX4 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 O46096 (/IMP) Q7K511 (/IMP)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
1 Q9C1X2 (/IC)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 Q8N465 (/TAS)
Nitrogen compound metabolic process GO:0006807
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
1 O23240 (/IGI)
Ether lipid biosynthetic process GO:0008611
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
1 O97157 (/ISS)
Photorespiration GO:0009853
A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria.
1 O23240 (/IGI)
Response to manganese ion GO:0010042
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
1 Q8CIM3 (/ISO)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 Q8CIM3 (/ISO)
Lactate biosynthetic process GO:0019249
The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid.
1 P39976 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 P39976 (/IMP)
Response to cobalt ion GO:0032025
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
1 Q8CIM3 (/ISO)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 Q8CIM3 (/ISO)
Lactate catabolic process GO:1903457
The chemical reactions and pathways resulting in the breakdown of lactate.
1 Q9C1X2 (/ISO)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
16 P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) Q11061 (/HDA)
(6 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
15 P32891 (/HDA) P32891 (/HDA) P32891 (/HDA) P32891 (/HDA) P32891 (/HDA) P32891 (/HDA) P46681 (/HDA) P46681 (/HDA) P46681 (/HDA) P46681 (/HDA)
(5 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
13 O23240 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) P84850 (/IDA) P84850 (/IDA) Q7TNG8 (/IDA)
(3 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
9 P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA) P9WIT1 (/HDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
8 A0A0G2K1W9 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) P32891 (/IDA) Q7TPJ4 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
7 P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA) P46681 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
6 P32891 (/TAS) P32891 (/TAS) P32891 (/TAS) P32891 (/TAS) P32891 (/TAS) P32891 (/TAS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
6 P32891 (/TAS) P32891 (/TAS) P32891 (/TAS) P32891 (/TAS) P32891 (/TAS) P32891 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 Q55BQ4 (/ISS) Q7TPJ4 (/ISS) Q86WU2 (/ISS) Q8CIM3 (/ISS) Q8N465 (/ISS)
Glycosome GO:0020015
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
2 Q585R0 (/IDA) Q585R0 (/IDA)
Glycosome lumen GO:0034468
The volume enclosed by the membrane of a glycosome.
2 Q585R0 (/IDA) Q585R0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P39976 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P39976 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8CIM3 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q7TNG8 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9C1X2 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8N465 (/TAS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 O96759 (/ISS)
Glycosome GO:0020015
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
1 Q7YWB6 (/EXP)
Glycosome GO:0020015
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
1 Q7YWB6 (/ISO)