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CATH Superfamily 1.10.45.10

Vanillyl-alcohol Oxidase; Chain A, domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vanillyl-alcohol Oxidase; Chain A, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: D-lactate dehydrogenase mitochondrial

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-lactate dehydrogenase (cytochrome). [EC: 1.1.2.4]
(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).
    		 93 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A178UIT0 A0A178UIT0 A6ZXF3
    (83 more...)
    (R)-2-hydroxyglutarate--pyruvate transhydrogenase. [EC: 1.1.99.40]
    (R)-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + (R)-lactate.
    • The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC 1.1.2.4 and is active with oxaloacetate as electron acceptor forming (R)-malate.
    		 50 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A0A0L8VSA6 A6ZXF3 A6ZXF3 A6ZXF3
    (40 more...)
    D-2-hydroxyglutarate dehydrogenase. [EC: 1.1.99.39]
    (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
    • The enzyme has no activity with NAD(+) or NADP(+), and was assayed in vitro using artificial electron acceptors.
    • It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers.
    		 3 B8B7X6 O23240 Q7XI14
    Alkylglycerone-phosphate synthase. [EC: 2.5.1.26]
    1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.
    • The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage.
    		 2 O96759 O97157
    D-lactate dehydrogenase (acceptor). [EC: 1.1.99.6]
    (R)-lactate + acceptor = pyruvate + reduced acceptor.
    • The enzyme from the archaeon Archaeoglobus fulgidus cannot utilize NAD(+), cytochrome C, methylene blue or dimethylnaphthoquinone as acceptors.
    • In vitro it is active with artificial electron acceptors such as 2,6- dichlorophenolindophenol, but the physiological acceptor is not yet known.
    		 1 O29853