The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 50: nesprin-2 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q6ZWQ0 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q8WXH0 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8WXH0 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Centrosome localization GO:0051642
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
2 Q6ZWQ0 (/IMP) Q8WXH0 (/IMP)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
1 Q8WXH0 (/IMP)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
1 Q6ZWQ0 (/ISO)
Nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration GO:0021817
The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.
1 Q6ZWQ0 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q6ZWQ0 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q8WXH0 (/ISS)
Nuclear migration along microfilament GO:0031022
The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.
1 Q6ZWQ0 (/IMP)
Nuclear migration along microfilament GO:0031022
The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.
1 Q8WXH0 (/ISS)
Centrosome localization GO:0051642
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
1 Q6ZWQ0 (/ISO)
Cytoskeletal anchoring at nuclear membrane GO:0090286
The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane.
1 Q8WXH0 (/IDA)
Cytoskeletal anchoring at nuclear membrane GO:0090286
The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane.
1 Q6ZWQ0 (/ISO)
Regulation of cilium assembly GO:1902017
Any process that modulates the frequency, rate or extent of cilium assembly.
1 Q6ZWQ0 (/IMP)

There are 30 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
4 A0A0A0MRE3 (/IDA) G3V5X4 (/IDA) Q6ZWQ0 (/IDA) Q8WXH0 (/IDA)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
3 A0A0A0MRE3 (/IDA) G3V5X4 (/IDA) Q8WXH0 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
3 A0A0A0MRE3 (/IDA) G3V5X4 (/IDA) Q8WXH0 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 Q6ZWQ0 (/IDA) Q8WXH0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8WXH0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6ZWQ0 (/ISO)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q6ZWQ0 (/ISO)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q6ZWQ0 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8WXH0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q6ZWQ0 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8WXH0 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q6ZWQ0 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q8WXH0 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q6ZWQ0 (/ISO)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
1 Q6ZWQ0 (/ISO)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
1 Q8WXH0 (/IDA)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
1 Q6ZWQ0 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q8WXH0 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q6ZWQ0 (/ISO)
Lamellipodium membrane GO:0031258
The portion of the plasma membrane surrounding a lamellipodium.
1 Q8WXH0 (/IDA)
Lamellipodium membrane GO:0031258
The portion of the plasma membrane surrounding a lamellipodium.
1 Q6ZWQ0 (/ISO)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
1 Q8WXH0 (/IDA)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
1 Q6ZWQ0 (/ISO)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q6ZWQ0 (/ISO)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
1 Q8WXH0 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
1 Q6ZWQ0 (/ISO)
Meiotic nuclear membrane microtubule tethering complex GO:0034993
A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.
1 Q8WXH0 (/IDA)
Meiotic nuclear membrane microtubule tethering complex GO:0034993
A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.
1 Q6ZWQ0 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 Q6ZWQ0 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q8WXH0 (/HDA)
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