The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47: Growth arrest specific 2 like 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
18 A4IFA0 (/ISS) D3ZR69 (/ISS) D3ZUE1 (/ISS) E1BHS6 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F6Z9H0 (/ISS) F7AII8 (/ISS) F7ELI1 (/ISS)
(8 more)
Cytoskeletal adaptor activity GO:0008093
The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way.
18 A4IFA0 (/ISS) D3ZR69 (/ISS) D3ZUE1 (/ISS) E1BHS6 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F6Z9H0 (/ISS) F7AII8 (/ISS) F7ELI1 (/ISS)
(8 more)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
9 A4IFA0 (/ISS) D3ZR69 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q8JZP9 (/ISS)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
9 D3ZUE1 (/ISS) E1BHS6 (/ISS) F6Z9H0 (/ISS) F7ELI1 (/ISS) G1M8E1 (/ISS) G1PRB7 (/ISS) G1QKQ7 (/ISS) G1SL12 (/ISS) Q5SSG4 (/ISS)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
2 Q5SSG4 (/ISO) Q8JZP9 (/ISO)
Cytoskeletal adaptor activity GO:0008093
The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way.
2 Q5SSG4 (/ISO) Q8JZP9 (/ISO)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 Q99501 (/IDA)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 Q8JZP9 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q5SSG4 (/ISO)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
18 A4IFA0 (/ISS) D3ZR69 (/ISS) D3ZUE1 (/ISS) E1BHS6 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F6Z9H0 (/ISS) F7AII8 (/ISS) F7ELI1 (/ISS)
(8 more)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
18 A4IFA0 (/ISS) D3ZR69 (/ISS) D3ZUE1 (/ISS) E1BHS6 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F6Z9H0 (/ISS) F7AII8 (/ISS) F7ELI1 (/ISS)
(8 more)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
9 A4IFA0 (/ISS) D3ZR69 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q8JZP9 (/ISS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
9 A4IFA0 (/ISS) D3ZR69 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q8JZP9 (/ISS)
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
9 A4IFA0 (/ISS) D3ZR69 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q8JZP9 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
9 A4IFA0 (/ISS) D3ZR69 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q8JZP9 (/ISS)
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
9 A4IFA0 (/ISS) D3ZR69 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q8JZP9 (/ISS)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
8 A4IFA0 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q99501 (/ISS)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
8 A4IFA0 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F7AII8 (/ISS) F7FHX8 (/ISS) G1LNU3 (/ISS) Q99501 (/ISS)
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
2 Q5SSG4 (/ISO) Q8JZP9 (/ISO)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
2 Q5SSG4 (/ISO) Q8JZP9 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8JZP9 (/ISO)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 Q8JZP9 (/ISO)
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
1 Q8JZP9 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q8JZP9 (/ISO)
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 Q99501 (/IDA)
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 Q8JZP9 (/ISO)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
17 A4IFA0 (/ISS) D3ZR69 (/ISS) D3ZUE1 (/ISS) E1BHS6 (/ISS) F1RFH0 (/ISS) F6SQ98 (/ISS) F6UQ63 (/ISS) F6Z9H0 (/ISS) F7AII8 (/ISS) F7ELI1 (/ISS)
(7 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q5SSG4 (/ISO) Q8JZP9 (/ISO)
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