The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 39: Transgelin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 P37802 (/IPI) P37802 (/IPI) P37802 (/IPI) P37802 (/IPI) P37802 (/IPI) P37802 (/IPI) P37802 (/IPI) P37802 (/IPI) P37802 (/IPI) P37802 (/IPI)
(11 more)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
13 P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA)
(3 more)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 P31232 (/TAS)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P31232 (/TAS)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
21 P37802 (/IDA) P37802 (/IDA) P37802 (/IDA) P37802 (/IDA) P37802 (/IDA) P37802 (/IDA) P37802 (/IDA) P37802 (/IDA) P37802 (/IDA) P37802 (/IDA)
(11 more)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
20 Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS) Q9UI15 (/TAS)
(10 more)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
13 P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS)
(3 more)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
8 Q01995 (/TAS) Q01995 (/TAS) Q01995 (/TAS) Q01995 (/TAS) Q01995 (/TAS) Q01995 (/TAS) Q01995 (/TAS) Q01995 (/TAS)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
3 A0A2R8QQS8 (/IMP) Q6TGT5 (/IMP) Q803W9 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
3 A0A2R8QQS8 (/IMP) Q6TGT5 (/IMP) Q803W9 (/IMP)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
2 P37804 (/ISO) Q9WVA4 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9R1Q8 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9R1Q8 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
13 P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS) P37802 (/TAS)
(3 more)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
13 P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA)
(3 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
13 P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA) P37802 (/HDA)
(3 more)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
3 A0A2R8QQS8 (/IMP) Q6TGT5 (/IMP) Q803W9 (/IMP)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 B9ENC8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9R1Q8 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 Q9R1Q8 (/HDA)
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