The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36: Actinin alpha 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vinculin binding GO:0017166
Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 P05095 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P05095 (/IDA)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 P05095 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P05095 (/IDA)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P05095 (/IGI)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
1 P05095 (/IGI)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 P05095 (/IEP)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 P05095 (/IGI)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
1 P05095 (/IGI)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
1 P05095 (/IDA)
Actin crosslink formation GO:0051764
The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
1 P05095 (/IDA)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Smooth muscle dense body GO:0030486
Electron-dense region associated with a smooth muscle contractile fiber.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Outer dense plaque of desmosome GO:0090636
The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Inner dense plaque of desmosome GO:0090637
The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Dense body GO:0097433
An electron dense body which may contain granules.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Terminal web GO:1990357
An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.
29 A0A091D150 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) A0A096NVR2 (/ISS) D2H5Q1 (/ISS)
(19 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 F5GXS2 (/IDA) F5GXS2 (/IDA) P05095 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
2 F5GXS2 (/IDA) F5GXS2 (/IDA)
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
1 P05095 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 P05095 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P05095 (/IDA)
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
1 P05095 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 P05095 (/IDA)
Macropinocytic cup GO:0070685
A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin.
1 P05095 (/IDA)
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