The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: protein-methionine sulfoxide oxidase MICAL3 isofor...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
10 D4A1F2 (/ISS) F1MF74 (/ISS) F1QH17 (/ISS) F1RA39 (/ISS) F6QZ15 (/ISS) G3MWR8 (/ISS) O94851 (/ISS) Q7RTP6 (/ISS) Q8BML1 (/ISS) Q8CJ19 (/ISS)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
9 D4A1F2 (/ISS) F1MF74 (/ISS) F1QH17 (/ISS) F6QZ15 (/ISS) G3MWR8 (/ISS) O94851 (/ISS) Q7RTP6 (/ISS) Q8BML1 (/ISS) Q8CJ19 (/ISS)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
9 D4A1F2 (/ISS) F1MF74 (/ISS) F1QH17 (/ISS) F6QZ15 (/ISS) G3MWR8 (/ISS) O94851 (/ISS) Q7RTP6 (/ISS) Q8BML1 (/ISS) Q8CJ19 (/ISS)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
5 D4A1F2 (/ISS) F1MF74 (/ISS) F1RA39 (/ISS) F6QZ15 (/ISS) Q8BML1 (/ISS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
3 O94851 (/IDA) Q7RTP6 (/IDA) Q8BML1 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 Q8BML1 (/ISO) Q8CJ19 (/ISO)
NAD(P)H oxidase activity GO:0016174
Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
1 Q8BML1 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 O94851 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 Q8BML1 (/ISO)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
1 Q8BML1 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
10 D4A1F2 (/ISS) F1MF74 (/ISS) F1QH17 (/ISS) F1RA39 (/ISS) F6QZ15 (/ISS) G3MWR8 (/ISS) O94851 (/ISS) Q7RTP6 (/ISS) Q8BML1 (/ISS) Q8CJ19 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
10 D4A1F2 (/ISS) F1MF74 (/ISS) F1QH17 (/ISS) F1RA39 (/ISS) F6QZ15 (/ISS) G3MWR8 (/ISS) O94851 (/ISS) Q7RTP6 (/ISS) Q8BML1 (/ISS) Q8CJ19 (/ISS)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
8 D4A1F2 (/ISS) F1MF74 (/ISS) F1QH17 (/ISS) F1RA39 (/ISS) F6QZ15 (/ISS) G3MWR8 (/ISS) Q8BML1 (/ISS) Q8CJ19 (/ISS)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
5 D4A1F2 (/ISS) F1MF74 (/ISS) F6QZ15 (/ISS) O94851 (/ISS) Q8BML1 (/ISS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
5 D4A1F2 (/ISS) F1MF74 (/ISS) F6QZ15 (/ISS) O94851 (/ISS) Q8BML1 (/ISS)
Positive regulation of transcription via serum response element binding GO:0010735
Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.
5 D4A1F2 (/ISS) F1MF74 (/ISS) F1RA39 (/ISS) F6QZ15 (/ISS) Q8BML1 (/ISS)
Sulfur oxidation GO:0019417
The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.
4 D4A1F2 (/ISS) F1MF74 (/ISS) F6QZ15 (/ISS) O94851 (/ISS)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
3 O94851 (/IDA) Q7RTP6 (/IDA) Q8BML1 (/IDA)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
2 O94851 (/IDA) Q7RTP6 (/IDA)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
2 Q8BML1 (/ISO) Q8CJ19 (/ISO)
Actin filament depolymerization GO:0030042
Disassembly of actin filaments by the removal of actin monomers from a filament.
2 Q8BML1 (/ISO) Q8CJ19 (/ISO)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 F1RA39 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 F1RA39 (/IMP)
Positive regulation of transcription via serum response element binding GO:0010735
Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.
1 O94851 (/IMP)
Positive regulation of transcription via serum response element binding GO:0010735
Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.
1 Q8BML1 (/ISO)
Sulfur oxidation GO:0019417
The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.
1 Q8BML1 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 O94851 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q8BML1 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 D4A1F2 (/ISS) F1MF74 (/ISS) F1QH17 (/ISS) F1RA39 (/ISS) F6QZ15 (/ISS) G3MWR8 (/ISS) Q8BML1 (/ISS) Q8CJ19 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O94851 (/IDA) Q7RTP6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8BML1 (/ISO) Q8CJ19 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q7RTP6 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8CJ19 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q7RTP6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8CJ19 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7RTP6 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8CJ19 (/ISO)
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