The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 18: Neuron navigator 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
6 E9Q842 (/IDA) Q3TYU9 (/IDA) Q8BJG0 (/IDA) Q8BYJ2 (/IDA) V9GX91 (/IDA) V9GXT3 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q5TZ18 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8IVL1 (/IPI)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q8IVL0 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q80TN7 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of systemic arterial blood pressure by baroreceptor feedback GO:0003025
The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control.
6 E9Q842 (/IMP) Q3TYU9 (/IMP) Q8BJG0 (/IMP) Q8BYJ2 (/IMP) V9GX91 (/IMP) V9GXT3 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
6 E9Q842 (/ISO) Q3TYU9 (/ISO) Q8BJG0 (/ISO) Q8BYJ2 (/ISO) V9GX91 (/ISO) V9GXT3 (/ISO)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
6 E9Q842 (/IMP) Q3TYU9 (/IMP) Q8BJG0 (/IMP) Q8BYJ2 (/IMP) V9GX91 (/IMP) V9GXT3 (/IMP)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
6 E9Q842 (/IMP) Q3TYU9 (/IMP) Q8BJG0 (/IMP) Q8BYJ2 (/IMP) V9GX91 (/IMP) V9GXT3 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
6 E9Q842 (/IMP) Q3TYU9 (/IMP) Q8BJG0 (/IMP) Q8BYJ2 (/IMP) V9GX91 (/IMP) V9GXT3 (/IMP)
Optic nerve development GO:0021554
The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
6 E9Q842 (/IMP) Q3TYU9 (/IMP) Q8BJG0 (/IMP) Q8BYJ2 (/IMP) V9GX91 (/IMP) V9GXT3 (/IMP)
Glossopharyngeal nerve development GO:0021563
Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.
6 E9Q842 (/IMP) Q3TYU9 (/IMP) Q8BJG0 (/IMP) Q8BYJ2 (/IMP) V9GX91 (/IMP) V9GXT3 (/IMP)
Vagus nerve development GO:0021564
The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
6 E9Q842 (/IMP) Q3TYU9 (/IMP) Q8BJG0 (/IMP) Q8BYJ2 (/IMP) V9GX91 (/IMP) V9GXT3 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
2 A0A0G2K833 (/IDA) F1LR12 (/IDA)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
1 Q8IVL0 (/IMP)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
1 Q80TN7 (/ISO)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q8IVL0 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q80TN7 (/ISO)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
1 Q5TZ18 (/IMP)
Positive regulation of microtubule polymerization GO:0031116
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
1 Q8IVL0 (/IMP)
Positive regulation of microtubule polymerization GO:0031116
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
1 Q80TN7 (/ISO)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
1 Q8IVL0 (/IMP)
Negative regulation of interleukin-2 production GO:0032703
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.
1 Q80TN7 (/ISO)
Liver morphogenesis GO:0072576
The process in which the anatomical structures of the liver are generated and organized.
1 Q5TZ18 (/IMP)
Positive regulation of invadopodium disassembly GO:1905929
Any process that activates or increases the frequency, rate or extent of invadopodium disassembly.
1 Q8IVL0 (/IMP)
Positive regulation of invadopodium disassembly GO:1905929
Any process that activates or increases the frequency, rate or extent of invadopodium disassembly.
1 Q80TN7 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Interstitial matrix GO:0005614
A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.
6 E9Q842 (/IDA) Q3TYU9 (/IDA) Q8BJG0 (/IDA) Q8BYJ2 (/IDA) V9GX91 (/IDA) V9GXT3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 E9Q842 (/ISO) Q3TYU9 (/ISO) Q8BJG0 (/ISO) Q8BYJ2 (/ISO) V9GX91 (/ISO) V9GXT3 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
6 E9Q842 (/IDA) Q3TYU9 (/IDA) Q8BJG0 (/IDA) Q8BYJ2 (/IDA) V9GX91 (/IDA) V9GXT3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 A0A0A0MTE8 (/IDA) A0A0A0MTL4 (/IDA) Q8IVL1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q80TN7 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q80TN7 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q5TZ18 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q5TZ18 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 Q5TZ18 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...