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CATH Superfamily 1.10.238.10

EF-hand

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 65: calpain-3 isoform X1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Calpain-3. [EC: 3.4.22.54]
Broad endopeptidase activity.
  • Activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site.
  • Substrates include the protein itself and connectin/titin.
  • Belongs to peptidase family C2.
 16 A0A2K6CWT0 A0A2K6CWT0 A0A2K6CWT0 F7G8S2 F7G8S2 F7G8S2 P16259 P20807 P43368 P51186
(6 more...)