The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histone, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Histone H2A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
256 C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO) C0HKE2 (/ISO)
(246 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
226 A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI) A4FTV9 (/IPI)
(216 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
114 P04908 (/NAS) P04908 (/NAS) P04908 (/NAS) P04908 (/NAS) P04908 (/NAS) P04908 (/NAS) P04908 (/NAS) P04908 (/NAS) P04908 (/NAS) P04908 (/NAS)
(104 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
55 P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI) P0C0S8 (/IPI)
(45 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
52 Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA)
(42 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
52 Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO)
(42 more)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
192 C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO) C0HKE5 (/ISO)
(182 more)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
116 P04908 (/IMP) P04908 (/IMP) P04908 (/IMP) P04908 (/IMP) P04908 (/IMP) P04908 (/IMP) P04908 (/IMP) P04908 (/IMP) P04908 (/IMP) P04908 (/IMP)
(106 more)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
66 A0A068L9C6 (/ISS) A0A087YBT0 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YRU2 (/ISS)
(56 more)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
66 A0A068L9C6 (/ISS) A0A087YBT0 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YRU2 (/ISS)
(56 more)
Membrane disruption in other organism GO:0051673
The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism.
66 A0A068L9C6 (/ISS) A0A087YBT0 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YRU2 (/ISS)
(56 more)
Nucleosome disassembly GO:0006337
The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
52 Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP)
(42 more)
Nucleosome disassembly GO:0006337
The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
52 Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO)
(42 more)
UV-damage excision repair GO:0070914
A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).
52 Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP) Q7L7L0 (/IMP)
(42 more)
UV-damage excision repair GO:0070914
A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).
52 Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO)
(42 more)
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
50 Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS) Q6GSS7 (/NAS)
(40 more)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
12 C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA)
(2 more)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
12 C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA)
(2 more)
Membrane disruption in other organism GO:0051673
The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism.
12 C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA)
(2 more)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
612 C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO) C0HKE1 (/ISO)
(602 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
467 P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA)
(457 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
346 P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA) P04908 (/HDA)
(336 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
324 P04908 (/IDA) P04908 (/IDA) P04908 (/IDA) P04908 (/IDA) P04908 (/IDA) P04908 (/IDA) P04908 (/IDA) P04908 (/IDA) P04908 (/IDA) P04908 (/IDA)
(314 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
71 P70082 (/TAS) P70082 (/TAS) P70082 (/TAS) P70082 (/TAS) P70082 (/TAS) P70082 (/TAS) P70082 (/TAS) P70082 (/TAS) P70082 (/TAS) P70082 (/TAS)
(61 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
66 A0A068L9C6 (/ISS) A0A087YBT0 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YI48 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YQB6 (/ISS) A0A087YRU2 (/ISS)
(56 more)
Nuclear nucleosome GO:0000788
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.
52 Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA) Q7L7L0 (/IDA)
(42 more)
Nuclear nucleosome GO:0000788
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.
52 Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO) Q8BFU2 (/ISO)
(42 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
12 C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA) C1BEH9 (/IDA)
(2 more)