The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histone, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: Nuclear transcription factor Y subunit beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
22 P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 P25208 (/ISA) P25208 (/ISA) P25208 (/ISA) P25208 (/ISA) P25208 (/ISA) P25208 (/ISA) P25208 (/ISA) P25208 (/ISA) P25208 (/ISA) P25208 (/ISA)
(9 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 P25208 (/ISM) P25208 (/ISM) P25208 (/ISM) P25208 (/ISM) P25208 (/ISM) P25208 (/ISM) P25208 (/ISM) P25208 (/ISM) P25208 (/ISM) P25208 (/ISM)
(9 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 P25208 (/NAS) P25208 (/NAS) P25208 (/NAS) P25208 (/NAS) P25208 (/NAS) P25208 (/NAS) P25208 (/NAS) P25208 (/NAS) P25208 (/NAS) P25208 (/NAS)
(9 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
19 P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS)
(9 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI)
(9 more)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
19 P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI) P25208 (/IPI)
(9 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 P63139 (/IDA) P63139 (/IDA) P63139 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 P63139 (/IGI) P63139 (/IGI) P63139 (/IGI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
3 P63140 (/IDA) P63140 (/IDA) P63140 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
19 P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA)
(9 more)
Regulation of cholesterol biosynthetic process GO:0045540
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
19 P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS)
(9 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
3 P63140 (/IC) P63140 (/IC) P63140 (/IC)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 P63139 (/IDA) P63139 (/IDA) P63139 (/IDA)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
3 P63139 (/IEP) P63139 (/IEP) P63139 (/IEP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
25 P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS) P25208 (/TAS)
(15 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
22 P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA)
(12 more)
CCAAT-binding factor complex GO:0016602
A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.
22 P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA)
(12 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
19 P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA)
(9 more)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
19 P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA) P25208 (/IDA)
(9 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
3 P63139 (/IC) P63139 (/IC) P63139 (/IC)
CCAAT-binding factor complex GO:0016602
A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
3 P63139 (/ISO) P63139 (/ISO) P63139 (/ISO)