The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transcription Factor, Ets-1
".
FunFam 22: Transcription factor CP2 like 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
15 |
A0A0G2JTJ9 (/IPI)
G3V969 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
(5 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
13 |
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
Q12800 (/ISA)
(3 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
13 |
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
Q12800 (/ISM)
(3 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
13 |
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
Q12800 (/NAS)
(3 more) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
13 |
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
(3 more) |
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
12 |
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
(2 more) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
12 |
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
(2 more) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
12 |
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
Q12800 (/IPI)
(2 more) |
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
1 | Q3UNW5 (/IDA) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q9ERA0 (/IDA) |
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q9ERA0 (/ISO) |
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q3UNW5 (/IC) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q9ERA0 (/IDA) |
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q9NZI6 (/TAS) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q9ERA0 (/ISO) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q9ERA0 (/ISO) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
13 |
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
Q12800 (/TAS)
(3 more) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
12 |
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
(2 more) |
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
|
12 |
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
(2 more) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q3UNW5 (/IDA) |
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
1 | Q3UNW5 (/IMP) |
Epithelial cell maturation GO:0002070
The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
|
1 | Q3UNW5 (/IMP) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q9ERA0 (/ISO) |
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
|
1 | Q9NZI6 (/TAS) |
Cytoplasm organization GO:0007028
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q3UNW5 (/IMP) |
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
|
1 | Q3UNW5 (/IMP) |
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
1 | Q9NZI6 (/TAS) |
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | Q3UNW5 (/IMP) |
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
|
1 | Q9ERA0 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9ERA0 (/TAS) |
Positive regulation of growth GO:0045927
Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
|
1 | Q3UNW5 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q9ERA0 (/IDA) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
27 |
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
(17 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
27 |
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
A0A024R120 (/IDA)
(17 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
13 |
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
(3 more) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
12 |
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
Q12800 (/IDA)
(2 more) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
12 |
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
Q12800 (/IMP)
(2 more) |
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
1 | Q9NZI6 (/IDA) |
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
1 | Q3UNW5 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9ERA0 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9ERA0 (/ISO) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | Q3UNW5 (/ISA) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | Q9ERA0 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q3UNW5 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9NZI6 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q3UNW5 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9ERA0 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q3UNW5 (/IDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q9ERA0 (/ISO) |