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CATH Superfamily 1.10.1040.10

N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: 3-hydroxyisobutyrate dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
    		 50 A0A024RA75 A0A024RA75 A0A024RA75 A0A024RA75 A0A024RA75 A0A024RA75 A0A0B4JCU8 A0A0B4JCU8 A0A2J8VDR4 A0A2J8VDR4
    (40 more...)
    L-serine 3-dehydrogenase (NAD(+)). [EC: 1.1.1.387]
    L-serine + NAD(+) = 2-aminoacetaldehyde + CO(2) + NADH.
    • The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103).
    • The enzyme has only very low activity with NADP(+) (cf. EC 1.1.1.276).
    		 2 A0A454LZS6 Q9I5I6