1 keywords

CATH Domain 6akwA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.58 Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous Superfamily 1.20.58.1470 FTO C-terminal domain

Domain Context

CATH Clusters

Superfamily FTO C-terminal domain
Functional Family FTO, alpha-ketoglutarate dependent dioxygenase

Enzyme Information

1.14.11.53
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q9C0B1
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt Q9C0B1

UniProtKB Entries (1)

Q9C0B1
FTO_HUMAN
Homo sapiens
Alpha-ketoglutarate-dependent dioxygenase FTO

PDB Structure

PDB 6AKW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang, Y., Su, R., Sheng, Y., Dong, L., Dong, Z., Xu, H., Ni, T., Zhang, Z.S., Zhang, T., Li, C., Han, L., Zhu, Z., Lian, F., Wei, J., Deng, Q., Wang, Y., Wunderlich, M., Gao, Z., Pan, G., Zhong, D., Zhou, H., Zhang, N., Gan, J., Jiang, H., Mulloy, J.C., Qian, Z., Chen, J., Yang, C.G.
Cancer Cell