CATH Domain 6akwA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.1470	FTO C-terminal domain

Domain Context

CATH Clusters

Superfamily	FTO C-terminal domain
Functional Family	FTO, alpha-ketoglutarate dependent dioxygenase

Enzyme Information

1.14.11.53

mRNA N(6)-methyladenine demethylase.

based on mapping to UniProt Q9C0B1

N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).

-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.

1.14.11.-

With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

based on mapping to UniProt Q9C0B1

UniProtKB Entries (1)

Q9C0B1

FTO_HUMAN

Homo sapiens

Alpha-ketoglutarate-dependent dioxygenase FTO

PDB Structure

PDB	6AKW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Huang, Y., Su, R., Sheng, Y., Dong, L., Dong, Z., Xu, H., Ni, T., Zhang, Z.S., Zhang, T., Li, C., Han, L., Zhu, Z., Lian, F., Wei, J., Deng, Q., Wang, Y., Wunderlich, M., Gao, Z., Pan, G., Zhong, D., Zhou, H., Zhang, N., Gan, J., Jiang, H., Mulloy, J.C., Qian, Z., Chen, J., Yang, C.G. Cancer Cell