CATH Domain 5i4iA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.970	Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

Domain Context

CATH Clusters

Superfamily	3.40.50.970
Functional Family	Transketolase

Enzyme Information

2.2.1.1

Transketolase.

based on mapping to UniProt P34736

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.

-!- Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH. -!- The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

UniProtKB Entries (1)

P34736

TKT_PICST

Scheffersomyces stipitis CBS 6054

Transketolase

PDB Structure

PDB	5I4I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and biochemical interrogation on transketolase from Pichia stipitis for new functionality Hsu, L.J., Hsu, N.S., Wang, Y.L., Wu, C.J., Li, T.L. Protein Eng. Des. Sel.