CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.970 | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains |
Domain Context
CATH Clusters
Superfamily | 3.40.50.970 |
Functional Family | Pyruvate decarboxylase isozyme |
Enzyme Information
4.1.1.74 |
Indolepyruvate decarboxylase.
based on mapping to UniProt P06169
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
-!- More specific than EC 4.1.1.1.
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4.1.1.- |
Carboxy-lyases.
based on mapping to UniProt P06169
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4.1.1.72 |
Branched-chain-2-oxoacid decarboxylase.
based on mapping to UniProt P06169
(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO(2).
-!- Acts on a number of 2-oxo acids, with a high affinity toward branched-chain substrates. -!- The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for biosynthesis of branched-chain fatty acids.
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4.1.1.43 |
Phenylpyruvate decarboxylase.
based on mapping to UniProt P06169
Phenylpyruvate = phenylacetaldehyde + CO(2).
-!- Also acts on (indol-3-yl)pyruvate.
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UniProtKB Entries (1)
P06169 |
PDC1_YEAST
Saccharomyces cerevisiae S288C
Pyruvate decarboxylase isozyme 1
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PDB Structure
PDB | 2W93 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Allosteric Activation of Pyruvate Decarboxylases. A Never-Ending Story.
J.Mol.Catal., B Enzym.
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