The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 635507: Endoribonuclease Dicer homolog 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
11 A0A060VZM9 (/IDA) A0A060Y3B2 (/IDA) D7F7W8 (/IDA) D7F7W9 (/IDA) D7F7X0 (/IDA) F4HQG6 (/IDA) Q09884 (/IDA) Q96C10 (/IDA) Q99J87 (/IDA) Q9BYX4 (/IDA)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 F4HQG6 (/IPI) P34529 (/IPI) P84634 (/IPI) Q3EBC8 (/IPI) Q8R5F7 (/IPI) Q96C10 (/IPI) Q9BYX4 (/IPI) Q9LXW7 (/IPI) Q9SP32 (/IPI)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
3 B5X2V9 (/ISS) Q8R5F7 (/ISS) Q99J87 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 Q09884 (/IDA) Q96C10 (/IDA) Q9BYX4 (/IDA)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
2 Q8R5F7 (/ISO) Q99J87 (/ISO)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
2 Q96C10 (/IDA) Q9BYX4 (/IDA)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
2 Q8R5F7 (/ISO) Q99J87 (/ISO)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
2 Q8R5F7 (/ISS) Q99J87 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q8R5F7 (/ISO) Q99J87 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q8R5F7 (/ISS) Q99J87 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 B0R1C5 (/IPI) F1R4B9 (/IPI)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 Q09884 (/IDA)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 Q9BYX4 (/TAS)
Ribonuclease III activity GO:0004525
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
1 P34529 (/IDA)
Ribonuclease III activity GO:0004525
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
1 P34529 (/IMP)
Deoxyribonuclease I activity GO:0004530
Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.
1 P34529 (/IDA)
Ribonuclease activity GO:0004540
Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
1 Q09884 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9BYX4 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8R5F7 (/ISO)
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
1 Q9BYX4 (/IPI)
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
1 Q8R5F7 (/ISO)
Euchromatin binding GO:1990188
Interacting selectively and non-covalently with euchromatin, a dispersed and relatively uncompacted form of chromatin.
1 Q09884 (/IDA)

There are 100 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
6 A0A060VZM9 (/IMP) A0A060Y3B2 (/IMP) D7F7W8 (/IMP) D7F7W9 (/IMP) D7F7X0 (/IMP) Q8R5F7 (/IMP)
Immune response involved in response to exogenous dsRNA GO:1902615
Any immune response that is involved in response to exogenous dsRNA.
5 A0A060VZM9 (/IMP) A0A060Y3B2 (/IMP) D7F7W8 (/IMP) D7F7W9 (/IMP) D7F7X0 (/IMP)
Production of ta-siRNAs involved in RNA interference GO:0010267
Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs.
4 F4HQG6 (/IMP) P84634 (/IMP) Q3EBC8 (/IMP) Q9LXW7 (/IMP)
Maintenance of DNA methylation GO:0010216
Any process involved in maintaining the methylation state of a nucleotide sequence.
3 P84634 (/IMP) Q3EBC8 (/IMP) Q9LXW7 (/IMP)
RNA virus induced gene silencing GO:0051214
Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing.
3 P84634 (/IGI) Q3EBC8 (/IGI) Q9LXW7 (/IGI)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 B0R1C5 (/IDA) F1R4B9 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 B0R1C5 (/IGI) F1R4B9 (/IGI)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 Q8R5F7 (/IMP) Q99J87 (/IMP)
Production of lsiRNA involved in RNA interference GO:0010599
Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions.
2 F4HQG6 (/IMP) P84634 (/IMP)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
2 P34529 (/IMP) Q9LXW7 (/IMP)
Negative regulation of RIG-I signaling pathway GO:0039536
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
2 Q96C10 (/IMP) Q99J87 (/IMP)
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
1 P34529 (/IMP)
DNA catabolic process, endonucleolytic GO:0000737
The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
1 P34529 (/IDA)
Cytokinesis by cell plate formation GO:0000911
The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana.
1 F4HQG6 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 P34529 (/IMP)
Apoptotic DNA fragmentation GO:0006309
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
1 P34529 (/IGI)
DNA-templated transcription, termination GO:0006353
The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.
1 P84634 (/IMP)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
1 Q09884 (/IDA)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
1 F4HQG6 (/ISS)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 P34529 (/IDA)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
1 Q8LMR2 (/IMP)
Olfactory learning GO:0008355
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
1 P34529 (/IMP)
Detection of virus GO:0009597
The series of events in which a stimulus from a virus is received and converted into a molecular signal.
1 Q9BYX4 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q96C10 (/ISS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q9BYX4 (/TAS)
Virus induced gene silencing GO:0009616
Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes.
1 P84634 (/IGI)
Virus induced gene silencing GO:0009616
Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes.
1 F4HQG6 (/IMP)
Embryonic pattern specification GO:0009880
The process that results in the patterns of cell differentiation that will arise in an embryo.
1 F4HQG6 (/IMP)
Flower development GO:0009908
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
1 F4HQG6 (/TAS)
Polarity specification of adaxial/abaxial axis GO:0009944
The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure.
1 A7LFZ6 (/IMP)
Vegetative phase change GO:0010050
Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development.
1 P84634 (/IMP)
Vegetative to reproductive phase transition of meristem GO:0010228
The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.
1 F4HQG6 (/IMP)
Production of ta-siRNAs involved in RNA interference GO:0010267
Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs.
1 A7LFZ6 (/IDA)
Maintenance of shoot apical meristem identity GO:0010492
The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
1 A7LFZ6 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q09884 (/IMP)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q9BYX4 (/TAS)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
1 Q9BYX4 (/IDA)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
1 Q8R5F7 (/ISO)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
1 Q8R5F7 (/ISS)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
1 Q09884 (/IDA)
Chromatin silencing by small RNA GO:0031048
Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region.
1 Q09884 (/TAS)
DsRNA fragmentation GO:0031050
Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function.
1 P34529 (/IDA)
Primary miRNA processing GO:0031053
Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.
1 F4HQG6 (/TAS)
Pre-miRNA processing GO:0031054
Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
1 P34529 (/IMP)
Sorocarp stalk cell differentiation GO:0031149
The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum.
1 Q86L44 (/IMP)
Negative regulation of type I interferon production GO:0032480
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q96C10 (/IDA)
Negative regulation of type I interferon production GO:0032480
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q99J87 (/IMP)
Negative regulation of type I interferon production GO:0032480
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q99J87 (/ISO)
Negative regulation of type I interferon production GO:0032480
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q9BYX4 (/TAS)
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q99J87 (/IMP)
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q96C10 (/ISS)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
1 Q9BYX4 (/IMP)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
1 Q8R5F7 (/ISO)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
1 Q8R5F7 (/ISS)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
1 Q9BYX4 (/TAS)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
1 Q9BYX4 (/IDA)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
1 Q9BYX4 (/IMP)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
1 Q8R5F7 (/ISO)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
1 Q8R5F7 (/ISS)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
1 Q9BYX4 (/TAS)
Co-transcriptional gene silencing by RNA interference machinery GO:0033562
A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin.
1 Q09884 (/IMP)
Regulation of type III interferon production GO:0034344
Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.
1 Q9BYX4 (/TAS)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 Q09884 (/IMP)
Production of miRNAs involved in gene silencing by miRNA GO:0035196
Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein.
1 Q8LMR2 (/IMP)
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
1 P34529 (/IMP)
MRNA cleavage involved in gene silencing by miRNA GO:0035279
The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.
1 F4HQG6 (/IMP)
Establishment of chromatin silencing at silent mating-type cassette GO:0035389
The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at silent mating-type loci.
1 Q09884 (/IMP)
Cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528
Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
1 Q9BYX4 (/TAS)
MDA-5 signaling pathway GO:0039530
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
1 Q9BYX4 (/IDA)
MDA-5 signaling pathway GO:0039530
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
1 Q8R5F7 (/ISO)
MDA-5 signaling pathway GO:0039530
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
1 Q8R5F7 (/ISS)
Negative regulation of MDA-5 signaling pathway GO:0039534
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.
1 Q96C10 (/IMP)
Negative regulation of MDA-5 signaling pathway GO:0039534
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.
1 Q99J87 (/ISO)
Negative regulation of MDA-5 signaling pathway GO:0039534
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.
1 Q99J87 (/ISS)
Negative regulation of RIG-I signaling pathway GO:0039536
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
1 Q96C10 (/IDA)
Negative regulation of RIG-I signaling pathway GO:0039536
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
1 Q99J87 (/ISO)
Regulation of development, heterochronic GO:0040034
Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
1 P34529 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 B5X2V9 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q9BYX4 (/TAS)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q96C10 (/IDA)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q99J87 (/ISO)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
1 Q96C10 (/IDA)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
1 Q99J87 (/IMP)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
1 Q99J87 (/ISO)
Seed morphogenesis GO:0048317
The process in which the anatomical structures of the seed are generated and organized.
1 F4HQG6 (/IMP)
Reproductive structure development GO:0048608
The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
1 A7LFZ6 (/IMP)
Regulation of histone H3-K9 methylation GO:0051570
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
1 Q09884 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 P84634 (/IGI)
Heterochromatin organization involved in chromatin silencing GO:0070868
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.
1 Q09884 (/IMP)
Regulation of chromatin silencing at centromere GO:0090052
Any process that modulates the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin.
1 Q09884 (/IMP)
Positive regulation of MDA-5 signaling pathway GO:1900245
Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway.
1 Q99J87 (/IMP)
Positive regulation of MDA-5 signaling pathway GO:1900245
Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway.
1 Q96C10 (/ISS)
Positive regulation of RIG-I signaling pathway GO:1900246
Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.
1 Q99J87 (/IMP)
Positive regulation of RIG-I signaling pathway GO:1900246
Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.
1 Q96C10 (/ISS)
Positive regulation of RNA interference GO:1900370
Any process that activates or increases the frequency, rate or extent of RNA interference.
1 Q86L44 (/IMP)
Immune response involved in response to exogenous dsRNA GO:1902615
Any immune response that is involved in response to exogenous dsRNA.
1 B5X2V9 (/ISS)
Positive regulation of termination of RNA polymerase II transcription GO:1904595
Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription.
1 Q09884 (/IMP)
Chromatin silencing at centromere outer repeat region GO:1990141
Repression of transcription of DNA at the outer repeat region of a regional centromere by altering the structure of chromatin.
1 Q09884 (/IMP)
Regulation of seed maturation GO:2000034
Any process that modulates the frequency, rate or extent of seed maturation.
1 F4HQG6 (/IMP)
Positive regulation of primary miRNA processing GO:2000636
Any process that activates or increases the frequency, rate or extent of primary microRNA processing.
1 P34529 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 F4HQG6 (/IDA) P34529 (/IDA) P84634 (/IDA) Q09884 (/IDA) Q86L44 (/IDA) Q9LXW7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A0A060VZM9 (/IDA) D7F7W8 (/IDA) P34529 (/IDA) Q09884 (/IDA) Q99J87 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 A0A060Y3B2 (/IDA) D7F7W9 (/IDA) D7F7X0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P34529 (/IDA) Q09884 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q09884 (/IDA)
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
1 Q09884 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9LXW7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9BYX4 (/TAS)
Nuclear dicing body GO:0010445
A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes.
1 F4HQG6 (/IDA)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
1 Q09884 (/NAS)
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
1 Q09884 (/IDA)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
1 Q09884 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 B5X2V9 (/ISS)
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