The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 635325: Thymidine kinase 2, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Deoxycytidine kinase activity GO:0004137
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
3 D3ZGQ2 (/IDA) P27707 (/IDA) P48769 (/IDA)
Deoxyguanosine kinase activity GO:0004138
Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).
3 Q16854 (/IDA) Q54UT2 (/IDA) Q9QX60 (/IDA)
Thymidine kinase activity GO:0004797
Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
2 Q9R088 (/ISS) Q9XZT6 (/ISS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
2 P27707 (/IDA) P48769 (/IDA)
Deoxynucleoside kinase activity GO:0019136
Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.
2 Q501D4 (/IDA) Q9XZT6 (/IDA)
Nucleoside kinase activity GO:0019206
Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.
2 P27707 (/EXP) Q16854 (/EXP)
Nucleoside kinase activity GO:0019206
Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.
2 P43346 (/ISO) Q9QX60 (/ISO)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P48769 (/IDA)
Deoxyadenosine kinase activity GO:0004136
Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+).
1 Q54YL2 (/IDA)
Deoxycytidine kinase activity GO:0004137
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
1 P48769 (/IMP)
Deoxycytidine kinase activity GO:0004137
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
1 P43346 (/ISO)
Deoxycytidine kinase activity GO:0004137
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
1 P43346 (/ISS)
Deoxycytidine kinase activity GO:0004137
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
1 P27707 (/TAS)
Deoxyguanosine kinase activity GO:0004138
Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).
1 Q9QX60 (/ISO)
Deoxyguanosine kinase activity GO:0004138
Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).
1 Q16854 (/TAS)
Thymidine kinase activity GO:0004797
Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
1 D3ZGQ2 (/IDA)
Thymidine kinase activity GO:0004797
Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
1 O00142 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P48769 (/IDA)
NADH dehydrogenase (ubiquinone) activity GO:0008137
Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
1 Q99LC3 (/IDA)
NADH dehydrogenase (ubiquinone) activity GO:0008137
Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
1 O95299 (/NAS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P43346 (/ISO)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q9XZT6 (/IDA)
Nucleoside kinase activity GO:0019206
Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.
1 O00142 (/TAS)
Pyrimidine deoxyribonucleoside binding GO:0032548
Interacting selectively and non-covalently with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose.
1 P48769 (/IDA)
Pyrimidine deoxyribonucleoside binding GO:0032548
Interacting selectively and non-covalently with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose.
1 P48769 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P27707 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P43346 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyrimidine nucleotide metabolic process GO:0006220
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
3 P43346 (/ISS) P48769 (/ISS) Q3MHR2 (/ISS)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
2 O00142 (/TAS) Q9QX60 (/TAS)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 A0A0G2K478 (/IMP) D3ZDE4 (/IMP)
Pyrimidine nucleoside salvage GO:0043097
Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.
2 O00142 (/TAS) P27707 (/TAS)
Purine-containing compound salvage GO:0043101
Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.
2 P27707 (/TAS) Q16854 (/TAS)
Deoxycytidine metabolic process GO:0046092
The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.
2 D3ZGQ2 (/IDA) P48769 (/IDA)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
1 Q99LC3 (/IDA)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
1 O95299 (/NAS)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
1 O95299 (/TAS)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 Q54YL2 (/IDA)
Nucleoside diphosphate phosphorylation GO:0006165
The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate.
1 Q9XZT6 (/IDA)
Deoxyguanosine salvage GO:0006180
Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis.
1 Q54UT2 (/IDA)
Pyrimidine nucleotide metabolic process GO:0006220
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 P27707 (/IDA)
Pyrimidine nucleotide metabolic process GO:0006220
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 P43346 (/ISO)
Pyrimidine nucleotide metabolic process GO:0006220
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 P27707 (/TAS)
TMP biosynthetic process GO:0006230
The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate.
1 Q9XZT6 (/ISS)
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
1 Q9R088 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q9QX60 (/IDA)
Guanosine metabolic process GO:0008617
The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution.
1 Q16854 (/TAS)
Deoxyribonucleotide metabolic process GO:0009262
The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 Q9R088 (/IMP)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 Q9XZT6 (/IDA)
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
1 P48769 (/IDA)
Mitochondrial DNA metabolic process GO:0032042
The chemical reactions and pathways involving mitochondrial DNA.
1 Q9R088 (/IMP)
Mitochondrial respiratory chain complex I assembly GO:0032981
The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
1 O95299 (/TAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q561S0 (/IEP)
DGTP metabolic process GO:0046070
The chemical reactions and pathways involving dGTP, guanosine triphosphate.
1 Q9QX60 (/IDA)
Deoxycytidine metabolic process GO:0046092
The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.
1 P48769 (/IMP)
Thymidine metabolic process GO:0046104
The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.
1 D3ZGQ2 (/IDA)
Purine deoxyribonucleoside metabolic process GO:0046122
The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).
1 Q16854 (/IDA)
Purine deoxyribonucleoside metabolic process GO:0046122
The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).
1 Q9QX60 (/ISO)
Nucleotide phosphorylation GO:0046939
The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.
1 Q9XZT6 (/IDA)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 A0A024R4B3 (/IDA) A0A087WXC5 (/IDA) D3ZGQ2 (/IDA) E7ESZ7 (/IDA) O95299 (/IDA) Q99LC3 (/IDA) Q9QX60 (/IDA) Q9R088 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 D6RFG8 (/IDA) F5CTF3 (/IDA) P27707 (/IDA) Q16854 (/IDA) Q501D4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P43346 (/ISO) Q9QX60 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9QX60 (/IDA) Q9XZT6 (/IDA)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
2 O95299 (/IDA) P34942 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 O00142 (/TAS) Q16854 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P48769 (/IDA) Q9QX60 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q99LC3 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9XZT6 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q16854 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9R088 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 O95299 (/TAS)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
1 Q99LC3 (/ISO)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
1 O95299 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P27707 (/TAS)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 Q99LC3 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...