View in Gene3D

CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 635325: Thymidine kinase 2, mitochondrial

There are 11 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Deoxyguanosine kinase. [EC: 2.7.1.113]
ATP + deoxyguanosine = ADP + dGMP.
  • Deoxyinosine can also act as acceptor.
 630 A0A011SJX5 A0A023DK18 A0A023PES5 A0A059N1X1 A0A061C9P2 A0A062X9H2 A0A062XQW9 A0A063X7A8 A0A068EAD1 A0A076GPR8
(620 more...)
Deoxyadenosine kinase. [EC: 2.7.1.76]
ATP + deoxyadenosine = ADP + dAMP.
  • Deoxyguanosine can also act as acceptor.
  • Possibly identical with EC 2.7.1.74.
 597 A0A011SJX5 A0A023DK18 A0A023PES5 A0A060R5T8 A0A060Z241 A0A061C7Y7 A0A062X9H2 A0A062XQW9 A0A063X7A8 A0A068EAD1
(587 more...)
Deoxycytidine kinase. [EC: 2.7.1.74]
NTP + deoxycytidine = NDP + dCMP.
  • Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.
 374 A0A023PES5 A0A061IKI6 A0A063X7A8 A0A069G4H8 A0A075R304 A0A076NYW5 A0A077EJM6 A0A077W250 A0A090IWK6 A0A096A680
(364 more...)
Deoxynucleoside kinase. [EC: 2.7.1.145]
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate.
  • The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases (EC 2.7.1.76 and EC 2.7.1.113) in its broad specificity for all four common 2'-deoxyribonucleosides.
 163 A0A023PES5 A0A076GPR8 A0A0B5NP22 A0A0B5R749 A0A0B5Z5I5 A0A0D0HY20 A0A0D0PMX7 A0A0D0QQN3 A0A0D1QYI0 A0A0D7XMT3
(153 more...)
Thymidine kinase. [EC: 2.7.1.21]
ATP + thymidine = ADP + thymidine 5'-phosphate.
  • Deoxyuridine can also act as acceptor.
  • dGTP can also act as donor.
  • The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118, and EC 2.7.4.9.
  • Formerly EC 2.7.1.75.
 12 A0A061ICV1 A0A0B2QJZ7 A0A0B2SQA3 G4VMF8 I1JZE8 I1KFZ4 O00142 P28855 Q540Z9 Q9N0C5
(2 more...)
UMP/CMP kinase. [EC: 2.7.4.14]
(1) ATP + (d)CMP = ADP + (d)CDP. (2) ATP + UMP = ADP + UDP.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.
  • This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.
  • dCMP can also act as acceptor.
  • Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.
  • Formerly EC 2.7.4.5.
 10 A0A0C3I2J3 A0A0E1LKE5 A0A142FAB4 A0A172XDJ7 A0A1L6CK95 D4G3A0 G4ENY4 I2C0D7 M4KTZ2 U2AJT8
NADH:ubiquinone reductase (H(+)-translocating). [EC: 1.6.5.3]
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
  • The complex is present in mitochondria and aerobic bacteria.
  • Breakdown of the complex can release EC 1.6.99.3.
  • In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH.
 2 A0A170ZEA3 B7P9V0
Methylcytosine dioxygenase. [EC: 1.14.11.n2]
DNA 5-methylcytosine + 2-oxoglutarate + O(2) = DNA 5-hydroxymethylcytosine + succinate + CO(2).
  • Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).
  • Might initiate a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system.
  • Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.
 1 A0A061I1Y8
DTMP kinase. [EC: 2.7.4.9]
ATP + dTMP = ADP + dTDP.
    		 1 H0DF36
    NADH dehydrogenase. [EC: 1.6.99.3]
    NADH + acceptor = NAD(+) + reduced acceptor.
    • After preparations have been subjected to certain treatments cytochrome c may act as acceptor.
    • Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment.
    • Present in a mitochondrial complex as EC 1.6.5.3.
    • Formerly EC 1.6.2.1.
    		 1 A0A170ZEA3
    NADH dehydrogenase (quinone). [EC: 1.6.5.11]
    NADH + a quinone = NAD(+) + a quinol.
    • Menaquinone or other quinones can act as acceptor.
    • Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.
    • Formerly EC 1.6.99.5.
    		 1 A0A170ZEA3
    CATH-Gene3D is a Global Biodata Core Resource Learn more...