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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 628382: Katanin p60 atpase-containing subunit

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Microtubule-severing ATPase. [EC: 3.6.4.3]
ATP + H(2)O = ADP + phosphate.
  • Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
 1138 A0A016V3W8 A0A022Q0M7 A0A023F4Y5 A0A023GKV8 A0A024G226 A0A024GL92 A0A024GMG1 A0A024RDP8 A0A024UER6 A0A024URM0
(1128 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 47 A0A061I7Y1 A0A074SVP7 A0A084GGN5 A0A086KIG4 A0A086L0T3 A0A086LH85 A0A086MAS6 A0A086QAM0 A0A086QZ75 A0A096P5B2
(37 more...)
Vesicle-fusing ATPase. [EC: 3.6.4.6]
ATP + H(2)O = ADP + phosphate.
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
 19 A0A024R2C5 A0A024R705 A0A084FUX2 A0A178VQU8 H2NWH7 H2QEN0 I7J8X2 K7BC82 O75351 P46467
(9 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 9 A0A060T4M9 A0A060TAS5 A0A0L1HMU5 A0A0L1HMY9 A0A0L1I154 A0A0P4UF64 A0A0P4UFB6 A0A161MRL8 A0A170ZSX4
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 5 A0A085M2U5 A0A085NCN2 A0A0V0X6E4 A0A0V1AGI2 A0A0V1LV92
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