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CATH Superfamily 3.30.450.20

PAS domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 87882: PAS sensor histidine kinase

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histidine kinase. [EC: 2.7.13.3]
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
 117 A0A077SID3 A0A090GMF5 A0A099SXZ5 A0A0A5I369 A0A0D1CKD9 A0A0D5LXZ2 A0A0D5M0Z1 A0A0D5M9S0 A0A0F5ATL2 A0A0F6A606
(107 more...)
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 39 A0A089NVZ9 A0A0B2P0S5 A0A0B2PDG7 A0A0B2PDG7 A0A0B2QBE1 A0A0B2RCX1 A0A0B2RCX1 A0A0B2RNK8 A0A0B2RNK8 A0A0B2SL76
(29 more...)
Protein-glutamate methylesterase. [EC: 3.1.1.61]
Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol.
  • Hydrolyzes the products of EC 2.1.1.77, EC 2.1.1.78, EC 2.1.1.80 and EC 2.1.1.100.
 17 A0A0J1BHM9 A0A120MZU9 A0A142XYB4 A0A1E3GX90 F2B0L3 K5DM72 L7C999 L7CQZ7 M2AB22 M2B160
(7 more...)
Diguanylate cyclase. [EC: 2.7.7.65]
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
 4 A0A1J5R8Y6 D8G759 H1WBC0 U2EJN3
Protein kinase C. [EC: 2.7.11.13]
ATP + a protein = ADP + a phosphoprotein.
  • A family of serine- and threonine-specific protein kinases that depend on lipids for activity.
  • They can be activated by calcium but have a requirement for the second messenger diacylglycerol.
  • Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways.
  • Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters.
  • Formerly EC 2.7.1.37.
 4 B9RKW8 B9RKW8 B9T0R3 B9T0R3
Protein-glutamate O-methyltransferase. [EC: 2.1.1.80]
S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
  • Forms ester groups with L-glutamate residues in a number of membrane proteins.
  • Formerly EC 2.1.1.24.
 1 F7PMY2
Phosphoserine phosphatase. [EC: 3.1.3.3]
O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.
    		 1 A0A0U5B714
    Phosphoribosylformylglycinamidine synthase. [EC: 6.3.5.3]
    ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine + L-glutamate.
      		 1 A0A0X8HDJ0
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