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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 262931: PhoP family transcriptional regulator

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cyclic-guanylate-specific phosphodiesterase. [EC: 3.1.4.52]
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
  • Inhibited by Ca(2+) and Zn(2+).
  • Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive.
  • It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
 18 A0A0F4HDI8 A0A0F4HDI8 A0A0N7CKX3 A0A0N7CKX3 A0A142KS65 A0A142KS65 A0A1F1SZH2 A0A1F1SZH2 B2GEW2 B2GEW2
(8 more...)
Protein-glutamine glutaminase. [EC: 3.5.1.44]
Protein L-glutamine + H(2)O = protein L-glutamate + NH(3).
  • Specific for the hydrolysis of the gamma-amide of glutamine substituted at the carboxyl position or both the alpha-amino and carboxyl positions, e.g., L-glutaminylglycine and L-phenylalanyl-L- glutaminylglycine.
 18 A0A0F4HDI8 A0A0F4HDI8 A0A0N7CKX3 A0A0N7CKX3 A0A142KS65 A0A142KS65 A0A1F1SZH2 A0A1F1SZH2 B2GEW2 B2GEW2
(8 more...)
Protein-serine/threonine phosphatase. [EC: 3.1.3.16]
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
  • A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48).
  • The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
 18 A0A0F4HDI8 A0A0F4HDI8 A0A0N7CKX3 A0A0N7CKX3 A0A142KS65 A0A142KS65 A0A1F1SZH2 A0A1F1SZH2 B2GEW2 B2GEW2
(8 more...)
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