×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 3.10.580.10

CBS-domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
CBS-domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Putative metal transporter CNNM3 isoform 2
987
3D
 5mmzA00 - 93.6
2
Magnesium/cobalt efflux protein CorC
923
3D
 4hg0A01 - 93.3
3
Protein kinase AMP-activated non-catalytic subunit gamma 1
480
3D
 2uv7A00 - 79.7
4
Protein kinase AMP-activated non-catalytic subunit gamma 2
457 - - 71.7
5
HlyC/CorC family transporter
343 - - 87.6
7
Arabinose 5-phosphate isomerase
278
3D
 3k2vB00 - 86.4
6
DUF21 and CBS domain protein
275 - - 98.8
8
Integral membrane protein TerC
247 - - 79.6
9
Glycine betaine/L-proline ABC transporter ATP-binding protein
219 - - 28.0
10
Chloride voltage-gated channel 6
179 - - 59.9
14
Cystathionine beta-synthase
161
3D
 4uuuB00 - 93.3
11
TerC family inner membrane protein
161 - - 48.9
12
DUF21 domain-containing protein
159
3D
 3hf7A00 - 72.2
13
Arabinose 5-phosphate isomerase
147 - - 20.2
15
DUF21 domain-containing protein
127 - - 84.3
16
Transcriptional repressor CcpN
127
3D
 3fwsB00 - 77.1
17
CBS domain-containing protein CBSX3, mitochondrial
114 - - 52.3
18
Chloride channel protein
113 - - 50.2
19
Chloride voltage-gated channel 2
111 - - 69.6
20
Glycine betaine/L-proline ABC transporter, ATP-binding protein
101 - - 15.1
21
DUF21 domain-containing protein At4g14240-like
100 - - 58.1
25
Magnesium transporter MgtE
96
3D
 5x9hB02 - 83.2
22
Cystathionine beta-synthase Cbs
93 - - 59.0
24
Chloride channel 2c
92 - - 85.6
23
Acetoin utilization protein AcuB
92 - - 13.3
28
Chloride channel protein
80
3D
 2pfiB01 - 90.7
27
Chloride channel protein
77 - - 75.4
26
Chloride channel protein
77 - - 72.8
29
Chloride channel protein
69 - - 42.7
30
Chloride channel protein
67 - - 64.2
31
Chloride channel protein
58 - - 83.8
33
Nuclear protein SNF4
53
3D
 3te5C01 - 60.7
32
Chloride channel protein
37 - - 84.4
49
Nuclear protein SNF4
37
3D
 3te5C02 - 61.8
34
Glycine betaine/choline ABC transporter ATP-binding protein
36 - - 40.3
35
Protein SDS23
34 - - 69.6
38
CBS domain-containing protein CBSX2, chloroplastic
32
3D
 4gqyD00 - 37.4
36
Chloride channel protein
31 - - 18.0
37
Transmembrane CBS domain transporter
29 - - 20.4
39
Putative arabinose 5-phosphate isomerase
28 - - 22.8
40
Chloride channel 6
28 - - 71.8
41
Cystathionine beta-synthase
27 - - 74.6
42
DUF21 domain-containing protein isoform A
25 - - 73.7
43
Sds23p
24 - - 60.1
44
Chloride channel protein
23 - - 62.9
45
Magnesium and cobalt transporter
22 - - 9.0
46
SNF1-related protein kinase regulatory subunit gamma-1-like
22 - - 22.6
47
Chloride channel protein
21 - - 35.6
48
Chloride channel 2c
21 - - 89.2
51
Chloride channel protein
18 - - 51.2
53
Unplaced genomic scaffold supercont1.12, whole genome shotgun sequence
18 - - 82.4
52
Cystathionine beta-synthase
18 - - 72.7
50
Chloride channel protein
18 - - 89.6
54
Magnesium transporter MgtE
17 - - 28.8
55
Arabinose 5-phosphate isomerase
17 - - 2.0
57
DUF21 domain-containing protein At5g52790
16 - - 75.0
56
Chloride channel protein
16 - - 64.6
63
DUF21 domain-containing protein At5g52790
15 - - 51.4
62
SNF1-related protein kinase regulatory subunit gamma-1-like
15 - - 15.8
58
Chloride channel protein
15 - - 75.8
61
Hemolysin-like protein containing CBS domains
15 - - 0.8
60
mRNA, clone: RTFL01-01-J02
15 - - 14.0
59
mRNA, clone: RTFL01-01-J02
15 - - 17.3
65
Protein MAM3
14 - - 1.1
64
Chloride channel protein
14 - - 22.3
67
Chloride channel protein
14 - - 43.2
66
Chloride channel protein
14 - - 79.3
68
DUF21 domain-containing protein At2g14520-like isoform X2
13 - - 25.8
69
CBS domain-containing protein
13 - - 12.5
70
Cyclin and CBS domain divalent metal cation transport mediator 4
12 - - 31.4
72
Putative zinc metalloprotease Rip3
12 - - 0.0
71
Hypoxic response protein 1
12 - - 0.0
76
Chloride channel protein
11 - - 15.3
73
CBS domain protein
11 - - 0.8
75
CBS domain-containing protein
11 - - 12.2
74
Membrane protein TerC
11 - - 0.0
77
Cystathionine beta-synthase
11 - - 40.5
79
DUF21 domain-containing protein At1g47330
9 - - 50.7
78
HlyC/CorC family transporter
9 - - 0.0
80
Chloride channel protein
9 - - 0.7
87
Chloride channel protein
8 - - 53.8
81
Chloride channel protein
8 - - 32.5
82
Chloride channel protein
8 - - 13.2
85
Membrane protein, TerC family/CBS domain/transporter associated domain protein
8 - - 15.5
83
HlyC/CorC family transporter
8 - - 0.0
84
Domain_of_uncharacterized_function_DUF21
8 - - 12.3
88
Glycine betaine/L-proline ABC transporter ATP-binding protein
8 - - 0.0
86
Protein MAM3, putative
8 - - 7.3
89
Chloride channel protein
8 - - 69.5
93
Chloride channel protein
7 - - 10.3
92
D-arabinose 5-phosphate isomerase
7 - - 3.6
91
CBS domain-containing protein CBSX6
7 - - 15.3
122
Cystathionine beta-synthase
7
3D
 3pc4A03 - 12.8
90
Magnesium transporter MgtE
7 - - 0.0
95
Formate transporter 1
6 - - 0.0
102
Chloride channel, voltage-sensitive 2a
6 - - 75.5
98
KpsF/GutQ family sugar-phosphate isomerase
6 - - 5.6
94
Magnesium transporter MgtE
6 - - 0.0
97
SNF1-related protein kinase regulatory subunit gamma-like PV42a
6 - - 39.3
100
Chloride channel protein
6 - - 13.4
99
Sugar isomerase, KpsF/GutQ family
6 - - 0.0
103
Chloride channel protein
6 - - 65.0
101
Predicted protein
6 - - 67.3
96
Magnesium and cobalt efflux protein CorC
6 - - 7.7
104
Chloride channel protein
5 - - 73.4
106
Putative manganese-dependent inorganic pyrophosphatase
5 - - 0.0
108
Putative cation efflux protein
5 - - 10.1
113
Chloride channel protein
5 - - 17.4
111
Chloride channel protein
5 - - 74.2
105
Inorganic pyrophosphatase
5 - - 12.2
110
Os03g0674300 protein
5 - - 14.3
107
Putative CBS domains protein
5 - - 7.1
109
SNF1-related protein kinase regulatory subunit gamma-like PV42b
5 - - 42.3
112
Chloride channel protein
5 - - 80.8
114
Chloride channel protein
5 - - 74.0
119
Chloride channel protein
4 - - 68.9
117
CBS-domain containing protein
4 - - 7.4
123
Metal transporter cnnm-2
4 - - 19.2
115
Manganese-dependent inorganic pyrophosphatase, putative
4 - - 6.9
121
Glycine betaine/carnitine/choline ABC transporter, ATP-binding protein
4 - - 6.4
124
Metal transporter cnnm-4
4 - - 35.7
118
Domain_of_uncharacterized_function_DUF21 /CBS_domain_containing_protein_-_putative
4 - - 4.1
120
Chloride channel protein
4 - - 83.6
116
Domain_of_uncharacterized_function_DUF21_-_putative
4 - - 10.5
127
Manganese-dependent inorganic pyrophosphatase, putative
3 - - 9.8
135
Uncharacterized protein
3 - - 0.0
137
Chloride channel protein
3 - - 0.0
125
Two-component sensor histidine kinase
3 - - 42.8
139
Uncharacterized protein
3 - - 30.7
133
Protein SDS23
3 - - 0.0
129
Predicted protein
3 - - 10.4
131
CBS domain containing protein
3 - - 0.0
128
CBS domain-containing protein
3 - - 7.0
134
CBS domain containing protein
3 - - 6.8
136
Chloride channel protein
3 - - 13.2
138
Chloride channel protein
3 - - 11.8
132
Uncharacterized protein
3 - - 30.5
126
Chloride channel protein
3 - - 0.0
130
Hemolysin
3 - - 0.0
155
UPF0053 protein sll1254
2 - - 0.0
179
Os03g0674300 protein
2 - - 28.8
173
Putative chloride channel
2 - - 8.5
157
Uncharacterized protein
2 - - 6.1
147
Inorganic pyrophosphatase
2 - - 0.0
145
Homoserine O-acetyltransferase
2 - - 8.2
171
Chloride channel protein
2 - - 0.0
160
AMP-activated protein kinase, gamma regulatory subunit
2 - - 0.9
159
AMP-activated protein kinase, gamma regulatory subunit
2 - - 0.0
153
Predicted protein
2 - - 3.7
177
Cystathionine beta-synthase
2 - - 0.0
141
Chloride channel protein
2 - - 8.9
175
Chloride channel protein
2 - - 0.0
164
Uncharacterized protein
Fragment
2 - - 9.8
166
Chloride channel protein A
2 - - 18.1
151
Metal transporter cnnm-5
2 - - 25.8
168
Chloride channel protein B
2 - - 29.0
149
Uncharacterized protein
2 - - 14.3
143
Meiotically up-regulated gene 70 protein
2 - - 0.0
162
Uncharacterized protein
2 - - 11.8
170
Chloride channel protein
2 - - 10.7
161
Predicted protein
2 - - 0.9
154
Uncharacterized protein
2 - - 0.0
156
Uncharacterized protein
2 - - 0.0
152
Uncharacterized protein
2 - - 35.2
158
Magnesium and cobalt efflux protein
2 - - 0.0
148
Os04g0644800 protein
2 - - 40.9
169
Chloride channel protein
2 - - 31.3
163
Uncharacterized protein
2 - - 0.0
142
Uncharacterized protein
2 - - 0.0
146
Chloride channel protein
2 - - 0.0
144
Chloride channel protein
2 - - 4.2
172
Chloride channel protein
2 - - 0.0
178
Cystathionine beta-synthase
2 - - 10.6
150
Uncharacterized protein
2 - - 12.1
174
Voltage-gated chloride channel
2 - - 7.6
176
Cystathionine beta-synthase
2 - - 0.0
165
Predicted protein
2 - - 46.8
140
Chloride channel protein
2 - - 28.4
167
Chloride channel protein C
2 - - 12.6
194
Uncharacterized protein
1 - - 0.0
196
Cystathionine beta synthase domain protein1
1 - - 0.0
198
Predicted protein
1 - - 0.0
211
Chloride channel protein 7
1 - - 0.0
192
Uncharacterized protein
1 - - 0.0
206
DUF21 domain-containing protein
1 - - 0.0
204
Hemolysin
1 - - 0.0
227
Chloride channel, voltage-sensitive Kb
1 - - 0.0
185
Predicted protein
1 - - 0.0
187
Cysteine synthase, putative
1 - - 0.0
202
CBS domain containing protein
1 - - 0.0
225
Chloride channel protein
1 - - 0.0
213
Chloride channel protein
1 - - 0.0
219
Chloride channel protein EriC
1 - - 0.0
208
Uncharacterized protein
1 - - 0.0
181
Chloride channel, voltage-sensitive 1a
1 - - 0.0
221
Uncharacterized protein
1 - - 0.0
190
Cysteine synthase, putative
1 - - 0.0
183
Uncharacterized protein
1 - - 0.0
189
Hemolysin protein
1 - - 0.0
217
Chloride channel protein
1 - - 0.0
200
Uncharacterized protein
1 - - 0.0
215
Voltage-gated chloride channel, CBS domain pair-containing, putative
1 - - 0.0
223
Uncharacterized protein
1 - - 0.0
195
Predicted protein
1 - - 0.0
197
Uncharacterized protein
1 - - 0.0
205
Uncharacterized protein
1 - - 0.0
222
Chloride channel protein
1 - - 0.0
210
Putative transport integral membrane protein
1 - - 0.0
186
Chloride channel protein
1 - - 0.0
184
Chloride channel protein
1 - - 0.0
188
Chloride channel protein
1 - - 0.0
226
Chloride channel protein
1 - - 0.0
224
Chloride channel protein
1 - - 0.0
182
Uncharacterized protein
1 - - 0.0
207
Uncharacterized protein
1 - - 0.0
193
Predicted protein
1 - - 0.0
199
Uncharacterized protein
1 - - 0.0
201
UPF0053 protein MG146
1 - - 0.0
191
Uncharacterized protein
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
220
Uncharacterized protein
1 - - 0.0
209
Uncharacterized protein
1 - - 0.0
218
Chloride channel
1 - - 0.0
203
Uncharacterized protein
1 - - 0.0
216
Chloride channel protein
1 - - 0.0
214
Protein CBR-CLH-6
1 - - 0.0
180
Uncharacterized protein
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...