PDB Information

PDB4NLD
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase.
Gentles, R.G., Ding, M., Bender, J.A., Bergstrom, C.P., Grant-Young, K., Hewawasam, P., Hudyma, T., Martin, S., Nickel, A., Regueiro-Ren, A., Tu, Y., Yang, Z., Yeung, K.S., Zheng, X., Chao, S., Sun, J.H., Beno, B.R., Camac, D.M., Chang, C.H., Gao, M., Morin, P.E., Sheriff, S., Tredup, J., Wan, J., Witmer, M.R., Xie, D., Hanumegowda, U., Knipe, J., Mosure, K., Santone, K.S., Parker, D.D., Zhuo, X., Lemm, J., Liu, M., Pelosi, L., Rigat, K., Voss, S., Wang, Y., Wang, Y.K., Colonno, R.J., Gao, M., Roberts, S.B., Gao, Q., Ng, A., Meanwell, N.A., Kadow, J.F.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-11-14
Resolution2.750
CATH Insert Date23 Mar, 2014

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 24 Mar, 2014 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
4nldA01 23 Apr, 2015 Holding pen
4nldA02 23 Apr, 2015 3.30.70.270 Assigned
4nldA03 23 Apr, 2015 Holding pen

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q9WMX2 POLG_HCVCO Hepatitis C virus (isolate Con1) Genome polyprotein
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