The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Reverse transcriptase/Diguanylate cyclase domain

This superfamily comprises structural domains found in several proteins such as reverse transcriptase PMID:23422558,PMID:20484498, INTERPRO:IPR000477, PFAM:PF00078, DNA polymerase IV INTERPRO:IPR022880 and several nucleotide cyclases, such as the nucleotide-binding GGDEF domain INTERPRO:IPR029787, INTERPRO:IPR000160.

The representative domains have DNA-directed DNA polymerase, RNA-directed RNA polymerase and diguanylate cyclase activities, and are involved in viral replication, signal transduction, nucleotide binding, hydrolysis of cyclic diguanylate PFAM:PF00990, [PfamClan:CL0276]

GO Diversity

Unique GO annotations
193 Unique GO terms

EC Diversity

Unique EC annotations
25 Unique EC terms

Species Diversity

Unique species annotations
23158 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2729
Domain clusters (>95% seq id): 102
Domain clusters (>35% seq id): 51
Unique PDBs: 944
Structural Clusters (5A): 7
Structural Clusters (9A): 6
FunFam Clusters: 339
Unique EC: 25
Unique GO: 193
Unique Species: 23158