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CATH Superfamily 3.30.70.270

Reverse transcriptase/Diguanylate cyclase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
6
Gag-Pol polyprotein
705
3D
 5k14A04 - 71.0
1
Diguanylate cyclase domain protein
606
3D
 3i5cB02 - 96.6
2
DNA polymerase IV
468
3D
 6ig1F01 - 94.0
4
Pol polyprotein
375
3D
 4ncgB02 - 88.5
3
Transposon Ty3-G Gag-Pol polyprotein
290
3D
 4ol8F01 - 83.3
5
DNA repair protein REV1
193
3D
 3gqcD01 - 61.9
61
DNA polymerase IV
190
3D
 4f4zB01 - 87.2
22
DNA polymerase eta
185
3D
 6mxoA01 - 86.2
15
Genome polyprotein
185
3D
 2xi3B03 - 79.2
8
Genome polyprotein
161 - - 78.6
7
Membrane-associated phosphodiesterase
161 - - 70.0
13
Polymerase
DNA directed
151
3D
 5ulxA01 - 87.6
9
Protein P
147 - - 62.8
10
DNA repair protein REV1
135 - - 74.6
11
DNA polymerase kappa
132 - - 65.3
12
DNA polymerase V subunit
114 - - 67.0
14
DNA polymerase kappa subunit
105 - - 95.5
16
POL polyprotein
83
3D
 1jlcB03 - 69.6
17
Predicted diguanylate cyclase
80 - - 86.6
20
Transposon Tf2-6 polyprotein-like Protein
78 - - 99.4
19
DNA repair protein REV1
78 - - 64.2
18
Diguanylate cyclase domain protein
78 - - 29.5
21
Genome polyprotein
69 - - 76.6
48
Gag-Pol polyprotein
57
3D
 6mikA01 - 23.3
23
Pol
54 - - 96.4
26
Transposon Ty3-G Gag-Pol polyprotein
49
3D
 4ol8B03 - 98.2
25
Retrovirus-related Pol polyprotein LINE-1
49 - - 52.7
24
Predicted diguanylate cyclase
49 - - 1.6
27
RNase E specificity factor CsrD
46 - - 76.6
28
Diguanylate cyclase domain protein
44 - - 4.6
29
DNA polymerase eta
40 - - 76.7
31
Genome polyprotein
38 - - 19.1
33
Probable diguanylate cyclase YeaP
38 - - 0.7
30
Genome polyprotein
38 - - 21.1
32
Cyclic di-GMP phosphodiesterase Gmr
38 - - 3.4
35
Diguanylate cyclase YdeH
37
3D
 3tvkA00 - 7.6
34
Diguanylate cyclase domain protein
37 - - 10.7
36
Diguanylate cyclase domain-containing protein
35 - - 9.7
37
Sensory box/GGDEF family protein
35 - - 13.6
38
Diguanylate cyclase domain protein
27 - - 15.2
42
Sensor domain-containing diguanylate cyclase
25
3D
 3qyyB00 - 94.7
39
Paternally expressed 10
24 - - 7.0
40
DNA repair protein REV1
24 - - 72.0
41
Uncharacterized protein
24 - - 91.1
43
Diguanylate cyclase
GGDEF
22 - - 20.4
44
Diguanylate cyclase
GGDEF
22 - - 92.0
45
Transposon Tf2-7 polyprotein
22 - - 89.4
46
Genome polyprotein
21 - - 76.1
47
Diguanylate cyclase
GGDEF
21 - - 0.0
49
Gag-Pol polyprotein
19 - - 19.1
50
DNA repair protein
19 - - 18.6
55
Sensor domain-containing diguanylate cyclase
18 - - 0.0
56
Sister chromatid cohesion protein Eso1
18 - - 83.9
51
Genome polyprotein
18 - - 42.6
52
DNA repair protein REV1
18 - - 30.8
53
DNA polymerase IV
18 - - 75.4
54
Putative DNA polymerase kappa
18 - - 72.3
58
Protein P
17 - - 78.2
57
DNA polymerase eta isoform X2
17 - - 25.3
91
DNA repair protein REV1
16
3D
 5wmbA02 - 47.4
60
Diguanylate cyclase
16 - - 59.1
63
Zinc knuckle domaincontaining protein
16 - - 97.0
62
Uncharacterized protein
16 - - 82.9
59
Diguanylate cyclase
GGDEF
16 - - 28.5
83
Genome polyprotein
15
3D
 1s4fD04 - 38.8
64
Diguanylate cyclase
15 - - 30.5
65
Genome polyprotein
15 - - 73.1
66
Endogenous retrovirus group K member 6 Pol protein
15 - - 76.0
68
Putative diguanylate cyclase
14 - - 67.4
67
DNA polymerase iota, putative
14 - - 60.9
69
Probable diguanylate cyclase DgcE
13 - - 13.5
70
DNA polymerase IV
13 - - 15.4
71
Sensor domain-containing diguanylate cyclase
13 - - 23.8
86
Protein FimX
13
3D
 3hvaB00 - 91.5
72
DNA polymerase IV
13 - - 14.8
73
Diguanylate cyclase
GGDEF
13 - - 8.7
76
Diguanylate cyclase
12 - - 11.8
77
DNA polymerase IV
12 - - 56.1
74
Diguanylate cyclase DosC
12 - - 0.7
75
Biofilm formation regulator HmsP
12 - - 12.3
78
Diguanylate cyclase response regulator
11 - - 0.0
80
Bifunctional diguanylate cyclase/phosphodiesterase
11 - - 0.0
82
DNA polymerase eta
11 - - 13.6
90
Diguanylate cyclase TpbB
11
3D
 4iobA00 - 5.8
81
Uncharacterized protein
11 - - 85.8
84
REV1, polymerase
DNA directed
11 - - 73.7
79
Diguanylate cyclase
11 - - 0.0
85
Endogenous retrovirus group K member 10 Pol protein
11 - - 46.4
89
Biofilm architecture maintenance protein mbaA
10 - - 8.3
92
Genome polyprotein
10 - - 21.9
93
Sensor domain-containing diguanylate cyclase
10 - - 63.8
87
YALI0E34980p
10 - - 80.3
88
GGDEF family protein
10 - - 6.1
99
DNA polymerase IV
9 - - 0.0
102
Putative DNA polymerase eta
9 - - 43.2
100
Uncharacterized protein
9 - - 97.5
101
DNA-directed polymerase kappa, putative
AFU_orthologue AFUA_7G01270
9 - - 68.1
96
Uncharacterized protein
9 - - 85.0
94
GGDEF family protein
9 - - 9.8
95
Bifunctional diguanylate cyclase/phosphodiesterase
9 - - 0.0
98
Diguanylate cyclase
9 - - 12.7
167
Response regulator PleD
9
3D
 2wb4B02 - 10.7
97
Related to DNA polymerase eta
9 - - 28.1
112
Uncharacterized protein
8 - - 8.0
105
Polyprotein
8 - - 0.0
111
Genome polyprotein
8 - - 19.8
113
DNA polymerase eta
8 - - 0.0
110
DNApol-iota, isoform A
8 - - 46.3
103
Sensory box/GGDEF family protein
8 - - 6.4
116
Sensory box/GGDEF family protein
8 - - 72.8
108
GGDEF family protein
8 - - 6.9
109
GGDEF family protein
8 - - 9.0
106
GGDEF family protein
8 - - 11.1
107
GGDEF domain-containing protein
8 - - 6.4
130
Diguanylate cyclase/phosphodiesterase
8
3D
 3pjxA01 - 22.7
115
Polyprotein of retroviral origin, putative
8 - - 92.8
114
Sensory box/GGDEF family protein
8 - - 0.0
104
Heme-regulated cyclic AMP phosphodiesterase
Direct oxygen sensor protein
8 - - 2.8
124
DNA repair protein REV1
7 - - 40.6
119
GGDEF family protein
7 - - 0.0
125
Uncharacterized protein
7 - - 77.5
118
GGDEF family protein
7 - - 0.0
117
GGDEF family protein
7 - - 2.7
120
Diguanylate cyclase
7 - - 0.0
121
AGAP001404-PA
7 - - 16.6
122
Uncharacterized protein
7 - - 79.9
123
Deoxycytidyl transferase, putative
7 - - 11.4
128
Transcriptional regulator CdgA
6 - - 11.8
132
Diguanylate cyclase
6 - - 0.0
129
GGDEF family protein
6 - - 0.0
131
Related to DNA repair protein MUS-42
6 - - 17.4
126
GGDEF family protein
6 - - 5.0
133
Diguanylate cyclase
GGDEF
6 - - 5.7
134
DNA polymerase kappa
6 - - 42.7
127
CRISPR-associated protein cas10/csm1, subtype III-a/mtube
6 - - 5.7
135
Uncharacterized protein
6 - - 94.3
142
Uncharacterized protein
5 - - 81.7
139
Pol polyprotein
5 - - 0.0
141
DNA polymerase eta subunit
5 - - 8.0
144
Uncharacterized protein
5 - - 75.8
143
5 - - 42.1
136
Diguanylate cyclase or phosphodiesterase
5 - - 5.0
137
Pol polyprotein
5 - - 3.4
138
Pro-Pol polyprotein
5 - - 15.6
140
Diguanylate cyclase-related enzyme
5 - - 0.0
158
DNA damage repair protein, putative
4 - - 6.1
149
Putative signal protein with GGDEF domain
4 - - 0.7
148
4 - - 3.1
157
4 - - 15.0
163
Retrovirus-related Pol polyprotein from transposon gypsy-like Protein
4 - - 84.6
156
4 - - 2.7
153
Uncharacterized protein
4 - - 69.2
155
4 - - 9.5
154
Pol polyprotein
4 - - 0.0
147
DNA polymerase Y family protein
4 - - 33.8
145
Uncharacterized protein
4 - - 82.6
152
Uncharacterized protein
4 - - 48.3
161
Transposon Tf2-9 polyprotein-like Protein
4 - - 0.0
146
4 - - 0.0
164
4 - - 71.3
160
GGDEF family protein
4 - - 9.3
151
Polymerase
DNA directed
4 - - 48.7
150
DNA polymerase eta
4 - - 58.3
159
Putative diguanylate cyclase YcdT
4 - - 0.0
162
Uncharacterized protein
4 - - 69.1
191
3 - - 68.4
170
Diguanylate cyclase/phosphodiesterase
GGDEF & EAL domain S
3 - - 11.1
184
Diguanylate cyclase/phosphodiesterase
GGDEF & EAL domains S
3 - - 2.6
181
3 - - 5.4
165
Response regulator ActA
3 - - 7.0
168
3 - - 0.0
178
3 - - 50.2
192
3 - - 48.0
183
PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase
3 - - 0.0
179
3 - - 81.6
193
3 - - 75.7
177
3 - - 31.2
186
Bifunctional diguanylate cyclase/phosphodiesterase
3 - - 7.5
171
3 - - 4.9
176
3 - - 17.8
166
3 - - 4.5
185
3 - - 0.0
180
3 - - 12.9
187
Uncharacterized protein
3 - - 4.2
175
3 - - 26.6
174
DNA polymerase kappa
3 - - 20.3
188
3 - - 9.0
189
3 - - 0.0
182
3 - - 13.2
173
3 - - 0.0
169
Putative diguanylate cyclase
3 - - 6.4
190
3 - - 60.1
172
Cyclic di-GMP phosphodiesterase Gmr
3 - - 0.0
232
2 - - 0.0
225
2 - - 0.0
207
2 - - 0.0
222
2 - - 0.0
217
2 - - 5.3
209
2 - - 0.0
224
2 - - 0.0
233
2 - - 0.0
199
2 - - 0.0
204
2 - - 0.0
248
2 - - 40.1
236
2 - - 0.0
234
2 - - 0.7
205
2 - - 0.0
227
2 - - 0.0
249
2 - - 21.7
214
2 - - 0.0
196
2 - - 0.0
194
2 - - 0.0
226
2 - - 0.0
244
2 - - 42.0
237
2 - - 27.1
235
2 - - 0.0
215
2 - - 0.0
246
2 - - 49.9
212
2 - - 41.0
198
2 - - 8.2
202
2 - - 37.2
229
2 - - 0.0
247
2 - - 48.6
210
2 - - 7.1
242
2 - - 2.0
213
2 - - 17.6
200
2 - - 0.0
195
2 - - 0.0
243
2 - - 37.7
203
2 - - 0.0
228
2 - - 7.9
238
2 - - 48.8
211
2 - - 28.2
218
2 - - 0.0
221
2 - - 0.0
240
2 - - 0.0
230
2 - - 1.5
239
2 - - 0.0
219
2 - - 8.2
206
2 - - 4.0
220
2 - - 2.7
197
2 - - 0.0
245
2 - - 44.8
208
2 - - 9.4
241
2 - - 41.2
201
2 - - 44.8
231
2 - - 6.0
223
2 - - 0.0
216
2 - - 0.0
311
1 - - 0.0
272
1 - - 0.0
294
1 - - 0.0
262
1 - - 0.0
278
1 - - 0.0
326
1 - - 0.0
335
1 - - 0.0
305
1 - - 0.0
281
1 - - 0.0
319
1 - - 0.0
336
1 - - 0.0
252
1 - - 0.0
329
1 - - 0.0
279
1 - - 0.0
263
1 - - 0.0
293
1 - - 0.0
310
1 - - 0.0
267
1 - - 0.0
280
1 - - 0.0
273
1 - - 0.0
334
1 - - 0.0
253
1 - - 0.0
258
1 - - 0.0
318
1 - - 0.0
337
1 - - 0.0
288
1 - - 0.0
260
1 - - 0.0
264
1 - - 0.0
259
1 - - 0.0
320
1 - - 0.0
338
1 - - 0.0
328
1 - - 0.0
297
1 - - 0.0
283
1 - - 0.0
295
1 - - 0.0
300
1 - - 0.0
296
1 - - 0.0
265
1 - - 0.0
256
1 - - 0.0
270
1 - - 0.0
261
1 - - 0.0
321
1 - - 0.0
282
1 - - 0.0
306
1 - - 0.0
285
1 - - 0.0
308
1 - - 0.0
301
1 - - 0.0
323
1 - - 0.0
330
1 - - 0.0
257
1 - - 0.0
307
1 - - 0.0
299
1 - - 0.0
315
1 - - 0.0
317
1 - - 0.0
284
1 - - 0.0
289
1 - - 0.0
290
1 - - 0.0
271
1 - - 0.0
309
1 - - 0.0
254
1 - - 0.0
322
1 - - 0.0
316
1 - - 0.0
314
1 - - 0.0
302
1 - - 0.0
298
1 - - 0.0
339
1 - - 0.0
268
1 - - 0.0
325
1 - - 0.0
287
1 - - 0.0
333
1 - - 0.0
255
1 - - 0.0
274
1 - - 0.0
303
1 - - 0.0
250
1 - - 0.0
276
1 - - 0.0
269
1 - - 0.0
313
1 - - 0.0
331
1 - - 0.0
324
1 - - 0.0
312
1 - - 0.0
286
1 - - 0.0
275
1 - - 0.0
251
1 - - 0.0
332
1 - - 0.0
292
1 - - 0.0
291
1 - - 0.0
327
1 - - 0.0
266
1 - - 0.0
277
1 - - 0.0
304
1 - - 0.0