CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.559 | Chloramphenicol Acetyltransferase |
|
3.30.559.10 | Chloramphenicol acetyltransferase-like domain |
Domain Context
CATH Clusters
| Superfamily | Chloramphenicol acetyltransferase-like domain |
| Functional Family | Vinorine synthase |
Enzyme Information
| 2.3.1.160 |
Vinorine synthase.
based on mapping to UniProt Q70PR7
Acetyl-CoA + 16-epivellosimine = CoA + vinorine.
-!- The reaction proceeds in two stages. -!- The indole nitrogen of 16-epivellosimine interacts with its aldehyde group giving an hydroxy-substituted new ring. -!- This alcohol is then acetylated. -!- Also acts on gardneral (11-methoxy-16-epivellosimine). -!- Generates the ajmalan skeleton, which forms part of the route to ajmaline.
|
UniProtKB Entries (1)
| Q70PR7 |
VINSY_RAUSE
Rauvolfia serpentina
Vinorine synthase
|
PDB Structure
| PDB | 2BGH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Vinorine Synthase, the First Representative of the Bahd Superfamily.
J.Biol.Chem.
|
