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CATH Superfamily 6.20.260.10

Adenylylsulphate reductase, beta subunit, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Adenylylsulphate reductase, beta subunit, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Adenylylsulphate reductase, beta subunit, C-terminal domain

The iron-sulfur flavoenzyme adenylylsulfate (adenosine 5'-phosphosulfate, APS) reductase catalyzes reversibly the reduction of APS to sulfite and AMP. It consists of two different subunits, alpha and beta, that are arranged as an alpha2beta2 heterotetramer. The alpha-subunit harbors the FAD cofactor and comprises an FAD-binding, a helical, and a capping domain; each of them an alpha/beta structure. This overall architecture classifies APS reductase as member of the fumarate reductase family.

The beta subunit consists of a bacterial ferredoxin-like segment carrying two [4Fe-4S] clusters, a three-stranded antiparallel beta-sheet, and a tail. Structural domains comprising this superfamily share the structure of the C-terminal region of this subunit which includes the beta-sheet and the C-terminal tail PMID:16503650,PMID:19820092,PMID:11842205.

GO Diversity

Unique GO annotations
6 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
410 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 18
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 7
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 6
Taxonomy
Unique Species: 410
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