The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Mediator complex, subunit Med21
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Mediator complex, subunit Med21

The Mediator complex is a co-activator involved in the regulated transcription of almost all RNA polymerase II-dependent genes. It remains bound to the promoter when transcriptional elongation begins, following the dissociation from the RNA polymerase II holoenzyme. The Mediator complex is composed of several subunits subunits and structural domains comprising this superfamily share the structure of subunit Med21. The different subunits form at least three structurally distinct submodules -head, middle and tail. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Med21 interacts with Med7 to form a heterodimer which is a highly conserved part of the mediator. This heterodimer has been shown to binds to other highly conserved Mediator subunits via its evolutionarily conserved regions and therefore plays a central architectural role within the Mediator PMID:15710619.

Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila PMID:15710619.

GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1288 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 24
Taxonomy
Unique Species: 1288
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