The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Nanos, RNA-binding domain
".
FunFam 1: nanos homolog 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
14 |
P25724 (/IPI)
P25724 (/IPI)
P60321 (/IPI)
P60321 (/IPI)
P60321 (/IPI)
P60322 (/IPI)
P60322 (/IPI)
P60323 (/IPI)
P60323 (/IPI)
P60323 (/IPI)
(4 more) |
Translation repressor activity GO:0030371
Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
|
5 | E7FDB3 (/ISS) Q80WY3 (/ISS) Q8WY41 (/ISS) Q90ZZ5 (/ISS) Q90ZZ6 (/ISS) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
3 | P60323 (/ISS) P60323 (/ISS) P60323 (/ISS) |
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
2 | P60322 (/IDA) P60322 (/IDA) |
Translation repressor activity GO:0030371
Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
|
2 | Q07937 (/IDA) Q07937 (/IDA) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | P60324 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q4QRE8 (/IPI) |
There are 56 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
7 | P60321 (/IDA) P60321 (/IDA) P60321 (/IDA) P60323 (/IDA) P60323 (/IDA) P60323 (/IDA) Q8WY41 (/IDA) |
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
7 | P60321 (/IDA) P60321 (/IDA) P60321 (/IDA) P60323 (/IDA) P60323 (/IDA) P60323 (/IDA) Q8WY41 (/IDA) |
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
|
6 | E7FDB3 (/IMP) P25724 (/IMP) P25724 (/IMP) P60323 (/IMP) P60323 (/IMP) P60323 (/IMP) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
6 | P60321 (/ISS) P60321 (/ISS) P60321 (/ISS) P60323 (/ISS) P60323 (/ISS) P60323 (/ISS) |
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
|
5 | P60324 (/ISS) Q07937 (/ISS) Q07937 (/ISS) Q90ZZ5 (/ISS) Q90ZZ6 (/ISS) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
5 | P25724 (/IMP) P25724 (/IMP) P60322 (/IMP) P60322 (/IMP) P60324 (/IMP) |
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
|
4 | Q07937 (/ISS) Q07937 (/ISS) Q90ZZ5 (/ISS) Q90ZZ6 (/ISS) |
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
4 | P60322 (/ISO) P60322 (/ISO) P60324 (/ISO) Q80WY3 (/ISO) |
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
4 | P60322 (/ISO) P60322 (/ISO) P60324 (/ISO) Q80WY3 (/ISO) |
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
|
3 | P60321 (/ISS) P60321 (/ISS) P60321 (/ISS) |
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
3 | P60323 (/ISS) P60323 (/ISS) P60323 (/ISS) |
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
|
3 | P60321 (/ISS) P60321 (/ISS) P60321 (/ISS) |
Negative regulation of meiotic nuclear division GO:0045835
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
|
3 | P60321 (/ISS) P60321 (/ISS) P60321 (/ISS) |
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
3 | P25724 (/IMP) P25724 (/IMP) P60324 (/IMP) |
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
3 | P60323 (/ISS) P60323 (/ISS) P60323 (/ISS) |
Oocyte growth GO:0001555
The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
|
2 | Q4QRE8 (/IMP) Q90WW1 (/IMP) |
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
|
2 | P25724 (/TAS) P25724 (/TAS) |
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
|
2 | P60322 (/IMP) P60322 (/IMP) |
Pole cell migration GO:0007280
The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
|
2 | P25724 (/TAS) P25724 (/TAS) |
Female gamete generation GO:0007292
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
|
2 | Q4QRE8 (/IMP) Q90WW1 (/IMP) |
Oocyte anterior/posterior axis specification GO:0007314
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
|
2 | P25724 (/NAS) P25724 (/NAS) |
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
|
2 | P25724 (/TAS) P25724 (/TAS) |
Anterior/posterior axis specification, embryo GO:0008595
The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
|
2 | P25724 (/TAS) P25724 (/TAS) |
Female meiosis chromosome segregation GO:0016321
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
|
2 | P25724 (/HMP) P25724 (/HMP) |
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | P25724 (/NAS) P25724 (/NAS) |
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | P25724 (/TAS) P25724 (/TAS) |
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
|
2 | P25724 (/IDA) P25724 (/IDA) |
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
|
2 | P60322 (/IMP) P60322 (/IMP) |
Segmentation GO:0035282
The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.
|
2 | P25724 (/IMP) P25724 (/IMP) |
Female germ-line stem cell population maintenance GO:0036099
The process by which an organism or tissue maintains a population of female germ-line stem cells.
|
2 | Q4QRE8 (/IMP) Q90WW1 (/IMP) |
Germ-line stem cell division GO:0042078
The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
|
2 | P25724 (/NAS) P25724 (/NAS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P25724 (/IGI) P25724 (/IGI) |
Negative regulation of meiotic nuclear division GO:0045835
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
|
2 | P60322 (/IMP) P60322 (/IMP) |
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
2 | P25724 (/IMP) P25724 (/IMP) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P25724 (/TAS) P25724 (/TAS) |
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
2 | P25724 (/IMP) P25724 (/IMP) |
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | Q80WY3 (/IGI) |
Tissue homeostasis GO:0001894
A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
|
1 | Q80WY3 (/IGI) |
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
1 | P60324 (/IEP) |
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
|
1 | P60324 (/ISO) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | P60324 (/IDA) |
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
|
1 | E7FDB3 (/IMP) |
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
|
1 | Q8WY41 (/IDA) |
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
|
1 | Q80WY3 (/IMP) |
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
|
1 | Q80WY3 (/ISO) |
Epithelial cell migration GO:0010631
The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.
|
1 | Q8WY41 (/IDA) |
Epithelial cell migration GO:0010631
The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.
|
1 | Q80WY3 (/ISO) |
Epithelial cell migration GO:0010631
The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.
|
1 | Q80WY3 (/ISS) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q8WY41 (/IDA) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q80WY3 (/ISO) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q80WY3 (/ISS) |
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
|
1 | A5Y5A4 (/IDA) |
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
1 | P60324 (/IDA) |
Cerebellar neuron development GO:0098749
The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
1 | Q80WY3 (/IMP) |
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P60324 (/IGI) |
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P60324 (/IMP) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
13 |
E7FDB3 (/IDA)
P60321 (/IDA)
P60321 (/IDA)
P60321 (/IDA)
P60322 (/IDA)
P60322 (/IDA)
P60323 (/IDA)
P60323 (/IDA)
P60323 (/IDA)
P60324 (/IDA)
(3 more) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
12 |
E7FDB3 (/IDA)
P60321 (/IDA)
P60321 (/IDA)
P60321 (/IDA)
P60322 (/IDA)
P60322 (/IDA)
P60323 (/IDA)
P60323 (/IDA)
P60323 (/IDA)
Q07937 (/IDA)
(2 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | P60321 (/IDA) P60321 (/IDA) P60321 (/IDA) P60323 (/IDA) P60323 (/IDA) P60323 (/IDA) P60324 (/IDA) |
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
6 | P60321 (/ISS) P60321 (/ISS) P60321 (/ISS) P60323 (/ISS) P60323 (/ISS) P60323 (/ISS) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
5 | P60322 (/ISS) P60322 (/ISS) Q80WY3 (/ISS) Q90ZZ5 (/ISS) Q90ZZ6 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | P60322 (/ISO) P60322 (/ISO) P60324 (/ISO) Q80WY3 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | Q07937 (/ISS) Q07937 (/ISS) Q90ZZ5 (/ISS) Q90ZZ6 (/ISS) |
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
|
4 | A7XBY3 (/IDA) A7XBY3 (/IDA) Q4QRE8 (/IDA) Q90WW1 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
4 | P60322 (/ISO) P60322 (/ISO) P60324 (/ISO) Q80WY3 (/ISO) |
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
3 | P60322 (/IDA) P60322 (/IDA) P60324 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P60322 (/ISO) P60322 (/ISO) P60324 (/ISO) |
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
3 | P60323 (/ISS) P60323 (/ISS) P60323 (/ISS) |
Germ plasm GO:0060293
Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.
|
3 | E7FDB3 (/IDA) Q07937 (/IDA) Q07937 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | P25724 (/IDA) P25724 (/IDA) |
Pole plasm GO:0045495
Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.
|
2 | P25724 (/TAS) P25724 (/TAS) |
Germ plasm GO:0060293
Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.
|
2 | Q90ZZ5 (/ISS) Q90ZZ6 (/ISS) |
Neuronal ribonucleoprotein granule GO:0071598
A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.
|
2 | P25724 (/IDA) P25724 (/IDA) |
Postsynapse of neuromuscular junction GO:0098975
The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.
|
2 | P25724 (/IMP) P25724 (/IMP) |
Messenger ribonucleoprotein complex GO:1990124
A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.
|
2 | P25724 (/IDA) P25724 (/IDA) |
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | P60324 (/IDA) |