The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Low-density Lipoprotein Receptor
".
FunFam 4: Low-density lipoprotein receptor-related protein 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 36 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
C0HL13 (/IPI)
E1BGJ0 (/IPI)
G3V928 (/IPI)
P98164 (/IPI)
P98164 (/IPI)
Q07954 (/IPI)
Q7Z5C0 (/IPI)
Q7Z5C0 (/IPI)
Q91ZX7 (/IPI)
Q9JI18 (/IPI)
(1 more) |
Lipoprotein particle binding GO:0071813
Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
|
8 | A8JRC4 (/IPI) A8JRC4 (/IPI) A8JRC7 (/IPI) A8JRC7 (/IPI) Q7YU01 (/IPI) Q7YU01 (/IPI) Q9VBN2 (/IPI) Q9VBN2 (/IPI) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
3 | P98164 (/IDA) P98164 (/IDA) Q91ZX7 (/IDA) |
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
3 | C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) |
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
|
3 | A8JRD0 (/IMP) Q07954 (/IMP) Q91ZX7 (/IMP) |
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
|
3 | C0HL13 (/IPI) P98164 (/IPI) P98164 (/IPI) |
Low-density lipoprotein particle receptor activity GO:0005041
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
|
2 | Q9JI18 (/IDA) Q9JI18 (/IDA) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
2 | C0HL13 (/ISS) Q07954 (/ISS) |
Alpha-2 macroglobulin receptor activity GO:0016964
Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.
|
2 | P98157 (/ISS) Q91ZX7 (/ISS) |
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
|
2 | Q9JI18 (/IDA) Q9JI18 (/IDA) |
Showing 1 to 10 of 36 entries
There are 146 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of lipid transport GO:0032370
Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
9 | A8JRC4 (/IMP) A8JRC4 (/IMP) A8JRC7 (/IMP) A8JRC7 (/IMP) Q7YU01 (/IMP) Q7YU01 (/IMP) Q91ZX7 (/IMP) Q9VBN2 (/IMP) Q9VBN2 (/IMP) |
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
|
6 | C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) Q07954 (/ISS) Q7Z5C0 (/ISS) Q7Z5C0 (/ISS) |
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
|
5 | P98164 (/TAS) P98164 (/TAS) Q07954 (/TAS) Q9NZR2 (/TAS) Q9NZR2 (/TAS) |
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
|
4 | A8JRD0 (/IMP) G3V928 (/IMP) Q07954 (/IMP) Q91ZX7 (/IMP) |
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
|
4 | A8JTM7 (/IMP) A8JTM7 (/IMP) Q95SN5 (/IMP) Q95SN5 (/IMP) |
Chitin-based cuticle development GO:0040003
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
|
4 | A8JTM7 (/IMP) A8JTM7 (/IMP) Q95SN5 (/IMP) Q95SN5 (/IMP) |
Regulation of adult chitin-containing cuticle pigmentation GO:0048082
Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
|
4 | A8JTM7 (/IMP) A8JTM7 (/IMP) Q95SN5 (/IMP) Q95SN5 (/IMP) |
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
|
3 | P98164 (/TAS) P98164 (/TAS) Q07954 (/TAS) |
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
3 | C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) |
Secondary heart field specification GO:0003139
The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
|
3 | C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) |
Showing 1 to 10 of 146 entries
There are 44 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
9 | P98164 (/HDA) P98164 (/HDA) Q07954 (/HDA) Q4ZG84 (/HDA) Q4ZG84 (/HDA) Q7Z5C0 (/HDA) Q7Z5C0 (/HDA) Q7Z5C1 (/HDA) Q7Z5C1 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | A8JRC4 (/IDA) A8JRC4 (/IDA) A8JRC7 (/IDA) A8JRC7 (/IDA) E1BGJ0 (/IDA) Q7YU01 (/IDA) Q7YU01 (/IDA) Q9VBN2 (/IDA) Q9VBN2 (/IDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
6 | A8JTM7 (/IDA) A8JTM7 (/IDA) P98164 (/IDA) P98164 (/IDA) Q95SN5 (/IDA) Q95SN5 (/IDA) |
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
5 | P98164 (/IDA) P98164 (/IDA) Q07954 (/IDA) Q9NZR2 (/IDA) Q9NZR2 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A8JTM7 (/HDA) A8JTM7 (/HDA) Q95SN5 (/HDA) Q95SN5 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | A8JTM7 (/HDA) A8JTM7 (/HDA) Q95SN5 (/HDA) Q95SN5 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P98164 (/TAS) P98164 (/TAS) Q07954 (/TAS) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
3 | C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | Q91ZX7 (/IDA) Q9JI18 (/IDA) Q9JI18 (/IDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
3 | C0HL13 (/ISS) P98164 (/ISS) P98164 (/ISS) |
Showing 1 to 10 of 44 entries