The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Low-density Lipoprotein Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24: Low-density lipoprotein RecePtor related

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Low-density lipoprotein particle receptor activity GO:0005041
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
2 O44191 (/IDA) Q9JI18 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O01768 (/IPI) Q9JI18 (/IPI)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 Q9Y5Q5 (/IDA)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 Q9Z319 (/IMP)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 Q9Z319 (/ISO)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 Q9Z319 (/ISS)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 Q9Y5Q5 (/TAS)
Vitellogenin receptor activity GO:0008196
Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis.
1 P98163 (/ISS)
Estrogen receptor activity GO:0030284
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
1 G0W2S9 (/IMP)
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
1 Q9JI18 (/IDA)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of systemic arterial blood pressure by atrial natriuretic peptide GO:0003050
The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
2 Q9Y5Q5 (/IMP) Q9Z319 (/IMP)
Regulation of systemic arterial blood pressure by atrial natriuretic peptide GO:0003050
The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
2 Q80YN4 (/ISS) Q9Y5Q5 (/ISS)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
2 Q9Y5Q5 (/IMP) Q9Z319 (/IMP)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
2 Q80YN4 (/IMP) Q9Z319 (/IMP)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
2 A8JTM7 (/IMP) Q95SN5 (/IMP)
Regulation of renal sodium excretion GO:0035813
Any process that modulates the amount of sodium excreted in urine over a unit of time.
2 Q80YN4 (/IMP) Q9Z319 (/IMP)
Chitin-based cuticle development GO:0040003
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
2 A8JTM7 (/IMP) Q95SN5 (/IMP)
Regulation of adult chitin-containing cuticle pigmentation GO:0048082
Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
2 A8JTM7 (/IMP) Q95SN5 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q9JI18 (/IMP)
Regulation of systemic arterial blood pressure by atrial natriuretic peptide GO:0003050
The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.
1 Q9Z319 (/ISO)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 Q9NZR2 (/TAS)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 Q9Z319 (/ISO)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 Q80YN4 (/ISS)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 Q9Z319 (/ISO)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 Q9Y5Q5 (/ISS)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 O44191 (/IMP)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9NZR2 (/TAS)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q9Y5Q5 (/IDA)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q9Z319 (/IMP)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q9Z319 (/ISO)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
1 Q80YN4 (/ISS)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q9Z319 (/ISO)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 O01768 (/IGI)
Ovulation GO:0030728
The release of a mature ovum/oocyte from an ovary.
1 O44191 (/IMP)
Regulation of renal sodium excretion GO:0035813
Any process that modulates the amount of sodium excreted in urine over a unit of time.
1 Q9Z319 (/ISO)
Regulation of renal sodium excretion GO:0035813
Any process that modulates the amount of sodium excreted in urine over a unit of time.
1 Q9Y5Q5 (/ISS)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 P98163 (/TAS)
Oocyte development GO:0048599
The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
1 O44191 (/IMP)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
1 Q9Y5Q5 (/TAS)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 A0A087X1D5 (/IDA) E7EQE7 (/IDA) J3KR88 (/IDA) J3KR90 (/IDA) O44191 (/IDA) Q9Y5Q5 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
5 A0A087X1D5 (/IDA) E7EQE7 (/IDA) J3KR88 (/IDA) J3KR90 (/IDA) Q9Y5Q5 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
5 A0A087X1D5 (/IDA) E7EQE7 (/IDA) J3KR88 (/IDA) J3KR90 (/IDA) Q9Y5Q5 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
3 O44191 (/IDA) P98163 (/IDA) Q80YN4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A8JTM7 (/HDA) Q95SN5 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 A8JTM7 (/HDA) Q95SN5 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 O44191 (/IDA) Q80YN4 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 A8JTM7 (/IDA) Q95SN5 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z319 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Y5Q5 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9Z319 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9Z319 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 O44191 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q9Z319 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9JI18 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q9Z319 (/ISO)
Coated vesicle GO:0030135
Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
1 P98163 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q9Z319 (/ISO)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9NZR2 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9JI18 (/ISO)
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