The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1microphthalmia-associated transcription factor isoform X1Circadian locomoter output cycles protein kaputT-cell acute lymphocytic leukemia 1Sterol regulatory element-binding transcription factor 1Myc-family transcription factorSC:2Myogenic factorNeurogenic differentiation factorMax dimerization protein 1MAX isoform 16DNA-binding protein inhibitor ID-2SC:3DNA-binding protein inhibitor ID-3Putative transcription factor 12Basic helix-loop-helix transcription factorBasic helix-loop-helix transcription factorsingle-minded homolog 1 isoform X1Nuclear receptor coactivatorTranscription factor HES-1Scleraxis bHLH transcription factorAryl hydrocarbon receptor nuclear translocator 2hairy/enhancer-of-split related with YRPW motif protein 1Transcription factor bHLH66Aryl hydrocarbon receptor nuclear translocator-like protein 1Myc proto-oncogene proteinclass E basic helix-loop-helix protein 40Transcription factor bHLH130 familyBasic helix-loop-helix transcription factorMAX isoform 13Aryl hydrocarbon receptor 2protein atonal homolog 7Basic helix-loop-helix family, member e23Nescient helix-loop-helix 1MLX interacting protein likeAchaete-scute family bHLH transcription factor 1Twist transcription factorOligodendrocyte transcription factor 3Transcription factor bHLH123 familyTranscription factor HES-5MAX network transcriptional repressorPancreas-specific transcription factor 1aTranscription factor AP-4max-like protein X isoform X2achaete-scute homolog 3MAX gene-associated protein isoform X1aryl hydrocarbon receptor repressortranscription factor bHLH48-like isoform X1Helix-loop-helix DNA binding proteinBasic helix-loop-helix transcription factorupstream stimulatory factor 2 isoform X1Transcription factor bHLH83mesoderm posterior protein 1DNA-binding protein inhibitor ID-4Basic helix-loop-helix transcription factorBasic helix-loop-helix domain-containing protein KIAA2018Protein atonal homolog 8BHLH transcription factorhairy and enhancer of split-related protein HELTmesogenin-1transcription factor-like 5 protein-liketranscription factor BEE 3-liketranscription factor UNE10 isoform X1Scute proteinTranscription factor SPEECHLESSNeuronal PAS domain-containing protein 3transcription factor HES-7 isoform X1Transcription factor MUTEclass A basic helix-loop-helix protein 15BHLH transcription factorupstream stimulatory factor 1 isoform X1factor in the germline alphaTranscription factor PIF7transcription factor bHLH30spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2enhancer of split mgamma protein-likeMAX dimerization protein 3Transcription factor ORG2Transcription factor bHLH113 familyhypoxia-inducible factor 3-alpha isoform X1transcription factor HES-3 isoform X2Transcription factor bHLH13CLUMA_CG001539, isoform ATaiman isoform Atranscription cofactor HES-6 isoform X1Transcription factor ILI6Neuronal PAS domain protein 1class A basic helix-loop-helix protein 9Transcription factor bHLH126protein extra-macrochaetaeTranscription factor hes-1HLH DNA binding proteinTranscription factor LAX PANICLESalivary gland-expressed bHLHHLH DNA binding domain proteintranscription factor bHLH68 isoform X1BHLH domain class transcription factorBlast:Carbohydrate-responsive element-binding proteinBasic helix-loop-helix family proteinBasic helix-loop-helix (BHLH) DNA-binding superfamily proteinNeuronal PAS domain-containing protein 2Sterol regulatory element-binding proteinTranscription factor BEE 3Transcription factor PRE4Nescient helix-loop-helix 1Transcription factor bHLH162Transcription factor bHLH34Rtg3pTranscription factor ILI5Basic helix-loop-helix transcription factorBasic helix-loop-helix transcription factorTranscription factor bHLH91-likeAspartyl-phosphate phosphatase Spo0EHLH transcription factor (Hpa3)Hes family bHLH transcription factor 6Transcription factor ILI1N-acetyl-gamma-glutamyl-phosphate partialTranscription factor bHLH113Putative HLH transcription factorOs01g0108400 proteinTranscription factor bHLH10Helix Loop HelixSpermatogenesis and oogenesis specific basic helix-loop-helix 1Serine-rich protein TYE7Retrograde regulation protein 1Transcription factor bHLH113transcription factor AP-4 isoform X3Transcription factor EGL1Protein WBSCR14 homologHelix-loop-helix protein 11Basic helix-loop-helix proteinHLH DNA binding protein (Penr2), putativeUnplaced genomic scaffold supercont1.11, whole genome shotgun sequenceBasic helix-loop-helix proteinCRE-HLH-2 proteinBHLH transcription factorMax-like protein XTranscription factor MYC1CBN-MXL-2 proteinTranscription factor bHLH52Basic helix-loop-helix (BHLH) DNA-binding superfamily proteinClockwork orange, isoform BHigh-copy mep suppressorBasic helix-loop-helix (BHLH) DNA-binding superfamily proteinSpermatogenesis and oogenesis specific basic helix-loop-helix 1Rtg1pUncharacterized proteinHelix-loop-helix DNA-binding domain containing protein, expressedTranscription factor bHLH162Transcription factor AP-4 (activating enhancer binding protein 4)Basic helix-loop-helix (BHLH) DNA-binding superfamily proteinRelated to centromere binding factor 1Mesoderm posterior protein 1Transcription factor HES-1-BNuclear pore complex protein NUP155Transcription factor bHLH167Protein CBR-HLH-12Upstream stimulatory factor 2Myogenic determination factorUncharacterized proteinSterol regulatory element Binding ProteinBasic helix-loop-helix (BHLH) DNA-binding superfamily proteinPutative transcription factor bHLH041Predicted proteinTranscription factor BHLH148Transcriptional regulator CBF1Putative dna-binding protein inhibitorTranscription factor bHLH104Transcription factor bHLH52Helix-loop-helix protein 6transcription factor proteinFI24210p1Putative myc-like protein MYCLP1Basic helix-loop-helix family proteinBasic helix-loop-helix (BHLH) DNA-binding superfamily proteinhelix-loop-helix protein delilahYALI0D24167pInhibitor of DNA binding 1Carbohydrate metabolism regulator TYE7Transcription factorUncharacterized proteinAryl hydrocarbon receptor nuclear translocator-like protein 2Transcription factor BPEHairy enhancer of splitBasic helix-loop-helixTranscription factor proteinUncharacterized proteinUncharacterized proteinTranscriptional regulator of yeast form adherence 6YALI0F05126pTranscription factor bHLH66Uncharacterized proteinProtein INO4, putativeTranscription factor UDT1Transcription factor bHLH109Uncharacterized proteinMax-like protein XcDNA FLJ52911, highly similar to Max-like protein XUncharacterized proteinPredicted proteinPolyadenylate-binding proteinUncharacterized proteinHms1pHms1pTranscription factor hes-1, putativeUncharacterized proteinNeuronal stem cell leukemia 2-like proteinREF-1Uncharacterized proteinTranscription factor bHLH117Predicted proteinUncharacterized proteinProtein CBG18500Uncharacterized proteinTranscription factor DYT1MAX-like-1 homologMLX-interacting protein-like proteinHER-2 proteinBHLH transcription factorUncharacterized proteinDNA binding proteinHairy-related 9Achaete-scute family bHLH transcription factor 4Uncharacterized protein ASH2Transcription factor bHLH99uncharacterized protein LOC100176581Uncharacterized proteinUncharacterized proteinUncharacterized proteinTranscription factor bHLH14Transcription factor bHLH95Uncharacterized proteinExtra macrochaetae-like proteinUncharacterized bHLH domain-containing protein C3F10.12cMAX dimerization protein MLXUncharacterized proteinHelix Loop HelixTranscription factor bHLH130Os03g0279500 proteinId-1Uncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinTranscription factor bHLH62Transcription factor, putativeUncharacterized proteinUncharacterized proteinPredicted protein
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FunFam 74: Transcription factor ORG2

GO Diversity

Unique GO annotations
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EC Diversity

Unique EC annotations
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Species Diversity

Unique species annotations
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Statistics

Members
CATH Domains: 0
Sequences: 51
Annotations
Unique GO: 14
Unique EC: 0
Unique Species: 24
Representative
Rep ID: Q9ZVB5/59-143
Inherited Annotations: 0
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