The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 23: MAX isoform 13
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 28 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
43 |
P28574 (/IPI)
P28574 (/IPI)
P28574 (/IPI)
P28574 (/IPI)
P52164 (/IPI)
P61244 (/IPI)
P61244 (/IPI)
P61244 (/IPI)
P61244 (/IPI)
P61244 (/IPI)
(33 more) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
41 |
P28574 (/ISS)
P28574 (/ISS)
P28574 (/ISS)
P28574 (/ISS)
P52164 (/ISS)
P61245 (/ISS)
P61245 (/ISS)
P61245 (/ISS)
P61245 (/ISS)
P61245 (/ISS)
(31 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
36 |
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
P61244 (/ISA)
(26 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
36 |
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
P61244 (/ISM)
(26 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
36 |
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
P61244 (/NAS)
(26 more) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
36 |
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
(26 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
36 |
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
(26 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
36 |
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
(26 more) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
36 |
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
(26 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
36 |
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
(26 more) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
36 |
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
(26 more) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
36 |
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
(26 more) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | P52164 (/IPI) P91664 (/IPI) P91664 (/IPI) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | P91664 (/IDA) P91664 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | P52164 (/IMP) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P52164 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P52164 (/IDA) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | P52164 (/IDA) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
38 |
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
(28 more) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
36 |
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
(26 more) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
36 |
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
(26 more) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
36 |
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
(26 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | P28574 (/IGI) P28574 (/IGI) P28574 (/IGI) P28574 (/IGI) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) P28574 (/IDA) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P91664 (/IDA) P91664 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P52164 (/IMP) |
|
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | P52164 (/IEP) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | P52161 (/IDA) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | P52161 (/IMP) |
|
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
1 | P52164 (/IEP) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P52164 (/IDA) |
|
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
1 | P52161 (/IMP) |
|
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | P52164 (/IEP) |
|
Determination of ventral identity GO:0048264
The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
1 | P52161 (/IGI) |
|
Determination of ventral identity GO:0048264
The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
1 | P52161 (/IMP) |
|
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
1 | P52164 (/IEP) |
|
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
|
1 | P52164 (/IEP) |
|
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
|
1 | P52164 (/IEP) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
1 | P52164 (/IDA) |
|
Protein trimerization GO:0070206
The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits.
|
1 | P52161 (/IPI) |
|
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | P52164 (/IEP) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
45 |
P28574 (/ISS)
P28574 (/ISS)
P28574 (/ISS)
P28574 (/ISS)
P52161 (/ISS)
P52162 (/ISS)
P52164 (/ISS)
P61245 (/ISS)
P61245 (/ISS)
P61245 (/ISS)
(35 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
43 |
P28574 (/IDA)
P28574 (/IDA)
P28574 (/IDA)
P28574 (/IDA)
P52164 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
(33 more) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
36 |
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
(26 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
36 |
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
P61244 (/TAS)
(26 more) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
36 |
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
P61244 (/IMP)
(26 more) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
36 |
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
(26 more) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
36 |
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
P61244 (/IDA)
(26 more) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
4 | P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) P28574 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P91664 (/IC) P91664 (/IC) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P52164 (/IDA) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
1 | P52164 (/IDA) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | P52164 (/IDA) |
|
SMAD protein complex GO:0071141
A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven.
|
1 | P52161 (/IPI) |
