The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
GPCR, family 2, extracellular hormone receptor domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29: PDF receptor isoform X3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcitonin receptor activity GO:0004948
Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
3 Q09460 (/ISS) Q9W4Y2 (/ISS) Q9W4Y2 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9W4Y2 (/IPI) Q9W4Y2 (/IPI)
Neuropeptide receptor activity GO:0008188
Combining with a neuropeptide to initiate a change in cell activity.
2 Q9W4Y2 (/IPI) Q9W4Y2 (/IPI)
Neuropeptide receptor activity GO:0008188
Combining with a neuropeptide to initiate a change in cell activity.
2 Q9W4Y2 (/ISM) Q9W4Y2 (/ISM)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q9W4Y2 (/ISM) Q9W4Y2 (/ISM)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q9W4Y2 (/ISS) Q9W4Y2 (/ISS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Gravitaxis GO:0042332
The directed movement of a motile cell or organism in response to gravity.
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
Circadian sleep/wake cycle GO:0042745
The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Regulation of circadian sleep/wake cycle GO:0042749
Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q9W4Y2 (/IGI) Q9W4Y2 (/IGI)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Circadian behavior GO:0048512
The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
Circadian behavior GO:0048512
The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Copper ion homeostasis GO:0055070
Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Circadian temperature homeostasis GO:0060086
Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.
2 Q9W4Y2 (/IMP) Q9W4Y2 (/IMP)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q09460 (/ISS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 Q09460 (/ISS)
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
1 Q09460 (/ISS)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9W4Y2 (/ISM) Q9W4Y2 (/ISM)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9W4Y2 (/ISS) Q9W4Y2 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9W4Y2 (/NAS) Q9W4Y2 (/NAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q9W4Y2 (/IDA) Q9W4Y2 (/IDA)
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