The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
GPCR, family 2, extracellular hormone receptor domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Glucagon like peptide 1 receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glucagon-like peptide 1 receptor activity GO:0044508
Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein.
2 O35659 (/ISS) P32301 (/ISS)
Peptide receptor activity GO:0001653
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
1 P32301 (/IDA)
Peptide receptor activity GO:0001653
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
1 O35659 (/ISO)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 P43220 (/TAS)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 P32301 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P43220 (/IPI)
G protein-coupled peptide receptor activity GO:0008528
Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 P32301 (/IPI)
G protein-coupled peptide receptor activity GO:0008528
Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 O35659 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 P32301 (/IDA)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 O35659 (/ISO)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 O35659 (/TAS)
Glucagon-like peptide 1 receptor activity GO:0044508
Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein.
1 P43220 (/IDA)
Glucagon-like peptide 1 receptor activity GO:0044508
Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein.
1 O35659 (/ISO)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2 O35659 (/ISS) P32301 (/ISS)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
2 O35659 (/TAS) P32301 (/TAS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
2 O35659 (/IMP) P32301 (/IMP)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
2 O35659 (/IDA) P32301 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P43220 (/TAS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P43220 (/IDA)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P32301 (/IMP)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 O35659 (/ISO)
Activation of adenylate cyclase activity GO:0007190
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
1 P43220 (/TAS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P43220 (/IDA)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 O35659 (/ISO)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 O35659 (/ISO)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P32301 (/IDA)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 O35659 (/ISO)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 P32301 (/IMP)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 O35659 (/ISO)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 O35659 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P32301 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 O35659 (/ISO)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
1 P32301 (/IDA)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
1 O35659 (/ISO)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P32301 (/IMP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 O35659 (/ISO)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 P43220 (/IDA)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 P32301 (/IMP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 O35659 (/ISO)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
1 P32301 (/IMP)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
1 O35659 (/ISO)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P32301 (/IDA)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 O35659 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P32301 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 O35659 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 P32301 (/IDA)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 O35659 (/ISO)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 P32301 (/IMP)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 O35659 (/ISO)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 O35659 (/ISO)
Positive regulation of heart contraction GO:0045823
Any process that activates or increases the frequency, rate or extent of heart contraction.
1 P32301 (/IDA)
Positive regulation of heart contraction GO:0045823
Any process that activates or increases the frequency, rate or extent of heart contraction.
1 O35659 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P32301 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O35659 (/ISO)
Hormone secretion GO:0046879
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
1 P32301 (/IDA)
Hormone secretion GO:0046879
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
1 O35659 (/ISO)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
1 P43220 (/TAS)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
1 P32301 (/IDA)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
1 O35659 (/ISO)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P32301 (/IMP)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O35659 (/ISO)
Response to psychosocial stress GO:1990911
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.
1 O35659 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P32301 (/TAS) P43220 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P32301 (/IDA) P43220 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P32301 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O35659 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O35659 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O35659 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O35659 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P43220 (/TAS)
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