The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Nucleoside Triphosphate Pyrophosphohydrolase
".
FunFam 34: Nucleotide triphosphate diphosphatase NUDT15
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity GO:0008413
Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.
|
7 | Q8BG93 (/IDA) Q9CA40 (/IDA) Q9CA40 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q9NV35 (/IPI) Q9NV35 (/IPI) Q9NV35 (/IPI) Q9NV35 (/IPI) |
|
Nucleoside-diphosphatase activity GO:0017110
Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.
|
4 | Q9NV35 (/EXP) Q9NV35 (/EXP) Q9NV35 (/EXP) Q9NV35 (/EXP) |
|
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity GO:0035539
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
|
4 | Q9NV35 (/EXP) Q9NV35 (/EXP) Q9NV35 (/EXP) Q9NV35 (/EXP) |
|
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity GO:0035539
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
|
4 | Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) |
|
Nucleoside-triphosphate diphosphatase activity GO:0047429
Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
|
4 | Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) |
|
Dihydroneopterin triphosphate pyrophosphohydrolase activity GO:0019177
Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate.
|
2 | Q9CA40 (/IDA) Q9CA40 (/IDA) |
|
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity GO:0008413
Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.
|
1 | Q8BG93 (/ISO) |
|
Nucleoside-diphosphatase activity GO:0017110
Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.
|
1 | Q8BG93 (/ISO) |
|
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity GO:0035539
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
|
1 | Q8BG93 (/ISO) |
|
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity GO:0035539
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
|
1 | Q8BG93 (/ISS) |
|
Nucleoside-triphosphate diphosphatase activity GO:0047429
Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
|
1 | Q8BG93 (/ISO) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
4 | Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) |
|
Purine nucleotide catabolic process GO:0006195
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
|
4 | Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) |
|
DGTP catabolic process GO:0006203
The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.
|
4 | Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) |
|
Nucleobase-containing small molecule catabolic process GO:0034656
The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
|
4 | Q9NV35 (/TAS) Q9NV35 (/TAS) Q9NV35 (/TAS) Q9NV35 (/TAS) |
|
DNA protection GO:0042262
Any process in which DNA is protected from damage by, for example, oxidative stress.
|
4 | Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) |
|
Exogenous drug catabolic process GO:0042738
The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.
|
4 | Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) |
|
Regulation of proteasomal protein catabolic process GO:0061136
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
|
4 | Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) |
|
Nucleoside phosphate catabolic process GO:1901292
The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate.
|
4 | Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) Q9NV35 (/IDA) |
|
Nucleoside phosphate catabolic process GO:1901292
The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate.
|
4 | Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) Q9NV35 (/IMP) |
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
2 | Q9CA40 (/IMP) Q9CA40 (/IMP) |
|
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
1 | Q8BG93 (/ISO) |
|
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
1 | Q8BG93 (/ISS) |
|
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
1 | Q8BG93 (/IDA) |
|
Purine nucleotide catabolic process GO:0006195
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
|
1 | Q8BG93 (/ISO) |
|
Purine nucleotide catabolic process GO:0006195
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
|
1 | Q8BG93 (/ISS) |
|
DGTP catabolic process GO:0006203
The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.
|
1 | Q8BG93 (/ISO) |
|
DGTP catabolic process GO:0006203
The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.
|
1 | Q8BG93 (/ISS) |
|
Purine deoxyribonucleoside triphosphate catabolic process GO:0009217
The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.
|
1 | Q8BG93 (/IDA) |
|
Exogenous drug catabolic process GO:0042738
The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.
|
1 | Q8BG93 (/ISO) |
|
Exogenous drug catabolic process GO:0042738
The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.
|
1 | Q8BG93 (/ISS) |
|
Regulation of proteasomal protein catabolic process GO:0061136
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
|
1 | Q8BG93 (/ISO) |
|
Regulation of proteasomal protein catabolic process GO:0061136
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
|
1 | Q8BG93 (/ISS) |
|
Nucleoside phosphate catabolic process GO:1901292
The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate.
|
1 | Q8BG93 (/ISO) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | Q9NV35 (/TAS) Q9NV35 (/TAS) Q9NV35 (/TAS) Q9NV35 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9CA40 (/IDA) Q9CA40 (/IDA) |
