CATH Superfamily 3.90.770.10
3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
".
FunFam 1: 3-hydroxy-3-methylglutaryl coenzyme A reductase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | P00347 (/IPI) P04035 (/IPI) P04035 (/IPI) P12683 (/IPI) P12684 (/IPI) P12684 (/IPI) P14891 (/IPI) P14891 (/IPI) Q10283 (/IPI) |
Hydroxymethylglutaryl-CoA reductase activity GO:0042282
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH.
|
6 | P00347 (/IDA) P04035 (/IDA) P04035 (/IDA) P14891 (/IDA) P14891 (/IDA) P51639 (/IDA) |
Hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0004420
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
|
5 | Q9KLM0 (/ISS) Q9KLM0 (/ISS) Q9KLM0 (/ISS) Q9KLM0 (/ISS) Q9KLM0 (/ISS) |
Hydroxymethylglutaryl-CoA reductase activity GO:0042282
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH.
|
4 | P14891 (/ISS) P14891 (/ISS) P43256 (/ISS) P43256 (/ISS) |
Hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0004420
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
|
3 | P12683 (/IDA) Q01237 (/IDA) Q10283 (/IDA) |
Hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0004420
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
|
3 | P12683 (/IGI) P12684 (/IGI) P12684 (/IGI) |
Hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0004420
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
|
2 | P12683 (/IMP) Q10283 (/IMP) |
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
|
2 | P04035 (/IDA) P04035 (/IDA) |
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
|
2 | P04035 (/IDA) P04035 (/IDA) |
Hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0004420
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
|
1 | A0A1D8PD39 (/NAS) |
Hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0004420
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
|
1 | C8VN86 (/RCA) |
Hydroxymethylglutaryl-CoA reductase activity GO:0042282
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH.
|
1 | Q01237 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P51639 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q01237 (/ISO) |
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
|
1 | Q01237 (/ISO) |
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | P51639 (/IPI) |
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | Q01237 (/ISO) |
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
|
1 | Q01237 (/ISO) |
There are 82 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Isoprenoid biosynthetic process GO:0008299
The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
|
7 | P14891 (/ISS) P14891 (/ISS) Q9KLM0 (/ISS) Q9KLM0 (/ISS) Q9KLM0 (/ISS) Q9KLM0 (/ISS) Q9KLM0 (/ISS) |
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
4 | P04035 (/IDA) P04035 (/IDA) P51639 (/IDA) Q01237 (/IDA) |
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
4 | A0A2R8QRF7 (/IMP) A2BGX2 (/IMP) A9JSZ0 (/IMP) Q1ECY4 (/IMP) |
Isoprenoid biosynthetic process GO:0008299
The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
|
4 | P14773 (/TAS) P14773 (/TAS) P43256 (/TAS) P43256 (/TAS) |
Triterpenoid biosynthetic process GO:0016104
The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.
|
4 | A0A0A1C3I2 (/IMP) A0A0A1C930 (/IMP) P43256 (/IMP) P43256 (/IMP) |
Sterol biosynthetic process GO:0016126
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
4 | P14891 (/IMP) P14891 (/IMP) P43256 (/IMP) P43256 (/IMP) |
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
|
2 | A0A0R4IFH5 (/IMP) Q58ER2 (/IMP) |
Blood vessel maturation GO:0001955
A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.
|
2 | A0A0R4IFH5 (/IMP) Q58ER2 (/IMP) |
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | A0A0R4IFH5 (/IMP) Q58ER2 (/IMP) |
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
2 | P04035 (/TAS) P04035 (/TAS) |
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
|
2 | P12684 (/ISA) P12684 (/ISA) |
Pole cell migration GO:0007280
The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
|
2 | P14773 (/IGI) P14773 (/IGI) |
Pole cell migration GO:0007280
The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
|
2 | P14773 (/IMP) P14773 (/IMP) |
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
|
2 | P14773 (/IMP) P14773 (/IMP) |
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
|
2 | P14773 (/IMP) P14773 (/IMP) |
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
|
2 | P14773 (/TAS) P14773 (/TAS) |
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
|
2 | P14773 (/TAS) P14773 (/TAS) |
Response to jasmonic acid GO:0009753
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
|
2 | A0A0A1C3I2 (/IEP) A0A0A1C930 (/IEP) |
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
2 | A0A0R4IFH5 (/IMP) Q58ER2 (/IMP) |
Saponin biosynthetic process GO:0016135
The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection.
|
2 | A0A0A1C3I2 (/IMP) A0A0A1C930 (/IMP) |
Ecdysis, chitin-based cuticle GO:0018990
The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster.
|
2 | P14773 (/IMP) P14773 (/IMP) |
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
2 | P04035 (/TAS) P04035 (/TAS) |
Isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287
The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.
|
2 | P14891 (/IDA) P14891 (/IDA) |
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
|
2 | P14773 (/IMP) P14773 (/IMP) |
Germ cell attraction GO:0035232
The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target.
|
2 | P14773 (/IDA) P14773 (/IDA) |
Germ cell attraction GO:0035232
The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target.
|
2 | P14773 (/TAS) P14773 (/TAS) |
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
2 | P04035 (/ISS) P04035 (/ISS) |
Regulation of cholesterol biosynthetic process GO:0045540
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
2 | P04035 (/TAS) P04035 (/TAS) |
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
2 | P14773 (/HGI) P14773 (/HGI) |
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
|
2 | A0A0R4IFH5 (/IMP) Q58ER2 (/IMP) |
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
|
2 | P04035 (/ISS) P04035 (/ISS) |
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
|
2 | P04035 (/IDA) P04035 (/IDA) |
Negative regulation of amyloid-beta clearance GO:1900222
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance.
|
2 | P04035 (/ISS) P04035 (/ISS) |
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | Q01237 (/ISO) |
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
|
1 | P12683 (/IMP) |
Ubiquinone metabolic process GO:0006743
The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme.
|
1 | P51639 (/IMP) |
Ubiquinone metabolic process GO:0006743
The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme.
|
1 | Q01237 (/ISO) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | P51639 (/IEP) |
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
|
1 | P51639 (/IEP) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P51639 (/IMP) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q01237 (/ISO) |
Isoprenoid biosynthetic process GO:0008299
The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
|
1 | P51639 (/IDA) |
Isoprenoid biosynthetic process GO:0008299
The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
|
1 | Q01237 (/ISO) |
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
|
1 | Q01237 (/IGI) |
Response to absence of light GO:0009646
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.
|
1 | A0A0A1C3I2 (/IEP) |
Farnesyl diphosphate biosynthetic process, mevalonate pathway GO:0010142
The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.
|
1 | Q10283 (/ISS) |
Farnesyl diphosphate biosynthetic process, mevalonate pathway GO:0010142
The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.
|
1 | P51639 (/TAS) |
Negative regulation of striated muscle cell apoptotic process GO:0010664
Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
|
1 | P51639 (/IMP) |
Negative regulation of striated muscle cell apoptotic process GO:0010664
Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
|
1 | Q01237 (/ISO) |
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
1 | P51639 (/IMP) |
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
1 | Q01237 (/ISO) |
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | C8VN86 (/RCA) |
Sterol biosynthetic process GO:0016126
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | A0A1D8PD39 (/NAS) |
Isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287
The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.
|
1 | P12683 (/IC) |
Isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287
The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.
|
1 | Q10283 (/IMP) |
Secondary metabolic process GO:0019748
The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
|
1 | C8VN86 (/IEP) |
Secondary metabolic process GO:0019748
The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
|
1 | C8VN86 (/IGC) |
Positive regulation of stress-activated MAPK cascade GO:0032874
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
|
1 | P51639 (/IMP) |
Positive regulation of stress-activated MAPK cascade GO:0032874
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
|
1 | Q01237 (/ISO) |
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | A0A1D8PD39 (/IMP) |
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
1 | Q01237 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P51639 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q01237 (/ISO) |
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
|
1 | Q01237 (/IGI) |
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
1 | P51639 (/IEP) |
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
1 | P51639 (/IEP) |
Positive regulation of skeletal muscle tissue development GO:0048643
Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
|
1 | P51639 (/IMP) |
Positive regulation of skeletal muscle tissue development GO:0048643
Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
|
1 | Q01237 (/ISO) |
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
1 | P51639 (/IMP) |
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
1 | Q01237 (/ISO) |
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
|
1 | Q01237 (/IMP) |
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
|
1 | Q01237 (/ISO) |
Negative regulation of wound healing GO:0061045
Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
|
1 | P51639 (/IMP) |
Negative regulation of wound healing GO:0061045
Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
|
1 | Q01237 (/ISO) |
Negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179
Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
|
1 | P51639 (/IMP) |
Negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179
Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
|
1 | Q01237 (/ISO) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P51639 (/IMP) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q01237 (/ISO) |
Negative regulation of blood vessel diameter GO:0097756
Any process that decreases the diameter of blood vessels.
|
1 | P51639 (/IMP) |
Negative regulation of blood vessel diameter GO:0097756
Any process that decreases the diameter of blood vessels.
|
1 | Q01237 (/ISO) |
Negative regulation of amyloid-beta clearance GO:1900222
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance.
|
1 | Q01237 (/IMP) |
N',N'',N'''-triacetylfusarinine C biosynthetic process GO:1900551
The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C.
|
1 | Q4WHZ1 (/IMP) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
5 | P12683 (/IDA) P12684 (/IDA) P12684 (/IDA) P14891 (/IDA) P14891 (/IDA) |
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
4 | P12683 (/IDA) P12684 (/IDA) P12684 (/IDA) Q10283 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
4 | P04035 (/IDA) P04035 (/IDA) P14891 (/IDA) P14891 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | P12684 (/HDA) P12684 (/HDA) Q10283 (/HDA) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
3 | P00347 (/TAS) P04035 (/TAS) P04035 (/TAS) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
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3 | P12683 (/HDA) P12684 (/HDA) P12684 (/HDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
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3 | P43256 (/IDA) P43256 (/IDA) P51639 (/IDA) |
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
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2 | P12684 (/IPI) P12684 (/IPI) |
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
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2 | P04035 (/IDA) P04035 (/IDA) |
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
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2 | P14773 (/ISS) P14773 (/ISS) |
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
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1 | Q01237 (/ISO) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
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1 | Q01237 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
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1 | A0A1D8PD39 (/IDA) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
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1 | Q10283 (/ISS) |
Nuclear outer membrane-endoplasmic reticulum membrane network GO:0042175
The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.
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1 | Q10283 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
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1 | Q01237 (/ISO) |