The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 74: Pro-cathepsin H

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 37 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
HLA-A specific activating MHC class I receptor activity GO:0030108
Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Thyroid hormone binding GO:0070324
Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
13 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(3 more)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
13 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(3 more)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
13 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(3 more)
Cysteine-type peptidase activity GO:0008234
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
13 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(3 more)
Cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656
Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.
13 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(3 more)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
2 P00786 (/IDA) P09668 (/IDA)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2 P09668 (/IDA) P49935 (/IDA)
Showing 1 to 10 of 37 entries

There are 66 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
15 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) F7BRD4 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS)
(5 more)
T cell mediated cytotoxicity GO:0001913
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Immune response-regulating signaling pathway GO:0002764
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Neuropeptide catabolic process GO:0010813
The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Bradykinin catabolic process GO:0010815
The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Showing 1 to 10 of 66 entries

There are 30 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
14 F6R7P5 (/ISS) F6X9C1 (/ISS) F7B939 (/ISS) F7BJD8 (/ISS) G1M0X4 (/ISS) G1RBY1 (/ISS) G1SQF0 (/ISS) G3R9A7 (/ISS) G3SSC1 (/ISS) O46427 (/ISS)
(4 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P00786 (/IDA) P09668 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 P00786 (/IDA) P09668 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A0A087X0D5 (/IDA) P09668 (/IDA)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
2 A0A087X0D5 (/IDA) P09668 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 A0A087X0D5 (/IDA) P09668 (/IDA)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
2 P00786 (/IDA) P09668 (/IDA)
Showing 1 to 10 of 30 entries
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