The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Lysine-specific histone demethylase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 53 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 A0A0G2K736 (/IPI) A8K2R3 (/IPI) B3STT9 (/IPI) F1MA31 (/IPI) O60341 (/IPI) Q6ZQ88 (/IPI) Q9VW97 (/IPI) Q9VW97 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 A0A0G2K736 (/IDA) B3STT9 (/IDA) F1MA31 (/IDA) O60341 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
4 A0A0G2K736 (/IPI) B3STT9 (/IPI) F1MA31 (/IPI) Q6ZQ88 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 O60341 (/IPI) Q6ZQ88 (/IPI)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Histone demethylase activity (H3-dimethyl-K4 specific) GO:0034648
Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.
2 O60341 (/IDA) Q6ZQ88 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q6ZQ88 (/IDA)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 Q6ZQ88 (/IPI)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 O60341 (/ISS)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 O60341 (/IPI)
Showing 1 to 10 of 53 entries

There are 99 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
6 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP) Q6ZQ88 (/IMP) Q9VW97 (/IMP) Q9VW97 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
4 A0A0P0UQI8 (/IMP) A0A2R8Q8P2 (/IMP) A0JMQ3 (/IMP) F6NIA2 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP) Q6ZQ88 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
4 A0A0G2K736 (/ISS) B3STT9 (/ISS) F1MA31 (/ISS) O60341 (/ISS)
Regulation of retinoic acid biosynthetic process GO:1900052
Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process.
4 A0A0P0UQI8 (/IGI) A0A2R8Q8P2 (/IGI) A0JMQ3 (/IGI) F6NIA2 (/IGI)
Regulation of hemopoiesis GO:1903706
Any process that modulates the frequency, rate or extent of hemopoiesis.
4 A0A0P0UQI8 (/IMP) A0A2R8Q8P2 (/IMP) A0JMQ3 (/IMP) F6NIA2 (/IMP)
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Showing 1 to 10 of 99 entries

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 A0A0G2K736 (/IDA) B3STT9 (/IDA) F1MA31 (/IDA) O60341 (/IDA) Q6ZQ88 (/IDA) Q9VW97 (/IDA) Q9VW97 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
5 A0A0G2K736 (/IDA) B3STT9 (/IDA) F1MA31 (/IDA) O60341 (/IDA) Q6ZQ88 (/IDA)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
2 Q9VW97 (/IPI) Q9VW97 (/IPI)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 O60341 (/IDA)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q6ZQ88 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q6ZQ88 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 O60341 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6ZQ88 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6ZQ88 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O60341 (/IDA)
Showing 1 to 10 of 18 entries
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