The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Histone acetyl transferase 1 (HAT1), N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Histone acetyltransferase type B catalytic subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA)
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
4 Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA)
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
4 Q12341 (/IMP) Q12341 (/IMP) Q12341 (/IMP) Q12341 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q12341 (/IPI) Q12341 (/IPI) Q12341 (/IPI) Q12341 (/IPI)
H4 histone acetyltransferase activity GO:0010485
Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.
4 Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
6 Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q59VF4 (/IDA) Q59VF4 (/IDA)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
4 Q12341 (/IGI) Q12341 (/IGI) Q12341 (/IGI) Q12341 (/IGI)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
4 Q12341 (/IMP) Q12341 (/IMP) Q12341 (/IMP) Q12341 (/IMP)
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
2 Q59VF4 (/IMP) Q59VF4 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 Q59VF4 (/IMP) Q59VF4 (/IMP)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
2 Q59VF4 (/IMP) Q59VF4 (/IMP)
Phenotypic switching GO:0036166
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2 Q59VF4 (/IMP) Q59VF4 (/IMP)
Negative regulation of pseudohyphal growth GO:2000221
Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth.
2 Q59VF4 (/IMP) Q59VF4 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q59VF4 (/IDA) Q59VF4 (/IDA)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
4 Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
4 Q12341 (/IPI) Q12341 (/IPI) Q12341 (/IPI) Q12341 (/IPI)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA) Q12341 (/IDA)
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