The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Transglutaminase-like
".
FunFam 1: Protein-glutamine gamma-glutamyltransferase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 23 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein-glutamine gamma-glutamyltransferase activity GO:0003810
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
|
8 | H0VK88 (/IDA) H0VT19 (/IDA) O95932 (/IDA) P00488 (/IDA) P22735 (/IDA) Q08188 (/IDA) Q6YCI4 (/IDA) Q8BM11 (/IDA) |
|
Protein-glutamine gamma-glutamyltransferase activity GO:0003810
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
|
8 | A6QP57 (/ISS) D4A5U3 (/ISS) O08619 (/ISS) P21980 (/ISS) P21980 (/ISS) P21980 (/ISS) Q08189 (/ISS) Q8BH61 (/ISS) |
|
Protein-glutamine gamma-glutamyltransferase activity GO:0003810
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
|
7 | P21980 (/IMP) P21980 (/IMP) P21980 (/IMP) P21981 (/IMP) Q8BH61 (/IMP) Q8IPH0 (/IMP) Q9VLU2 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | P08587 (/IPI) P21980 (/IPI) P21980 (/IPI) P21980 (/IPI) P22735 (/IPI) Q6P6R6 (/IPI) Q9WVJ6 (/IPI) |
|
Protein-glutamine gamma-glutamyltransferase activity GO:0003810
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
|
6 | P21981 (/ISO) Q08189 (/ISO) Q6YCI4 (/ISO) Q8BH61 (/ISO) Q8BM11 (/ISO) Q9JLF6 (/ISO) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
3 | A6QP57 (/ISS) D4A5U3 (/ISS) Q08189 (/ISS) |
|
Protein-glutamine gamma-glutamyltransferase activity GO:0003810
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
|
2 | P23606 (/NAS) P49221 (/NAS) |
|
Protein-glutamine gamma-glutamyltransferase activity GO:0003810
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
|
2 | O43548 (/TAS) P00488 (/TAS) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
2 | Q6P6R6 (/IDA) Q9WVJ6 (/IDA) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
2 | Q6P6R6 (/IC) Q9WVJ6 (/IC) |
Showing 1 to 10 of 23 entries
There are 76 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peptide cross-linking GO:0018149
The formation of a covalent cross-link between or within protein chains.
|
5 | H0VK88 (/IDA) H0VT19 (/IDA) P00488 (/IDA) P22735 (/IDA) Q08188 (/IDA) |
|
Peptide cross-linking GO:0018149
The formation of a covalent cross-link between or within protein chains.
|
5 | A6QP57 (/ISS) D4A5U3 (/ISS) O08619 (/ISS) Q08189 (/ISS) Q8BH61 (/ISS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
5 | P21980 (/IMP) P21980 (/IMP) P21980 (/IMP) Q6P6R6 (/IMP) Q9WVJ6 (/IMP) |
|
Positive regulation of keratinocyte proliferation GO:0010838
Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
|
4 | P22758 (/ISS) P23606 (/ISS) Q9GLK0 (/ISS) Q9JLF6 (/ISS) |
|
Negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471
Any process that decreases the concentration of calcium ions in the endoplasmic reticulum.
|
4 | P21980 (/IMP) P21980 (/IMP) P21980 (/IMP) P21981 (/IMP) |
|
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
|
4 | P22758 (/ISS) P23606 (/ISS) Q9GLK0 (/ISS) Q9JLF6 (/ISS) |
|
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
|
4 | P21980 (/IMP) P21980 (/IMP) P21980 (/IMP) P21981 (/IMP) |
|
Peptide cross-linking GO:0018149
The formation of a covalent cross-link between or within protein chains.
|
3 | Q08189 (/ISO) Q8BH61 (/ISO) Q9JLF6 (/ISO) |
|
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
|
3 | P21980 (/IDA) P21980 (/IDA) P21980 (/IDA) |
|
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
|
3 | P21980 (/ISS) P21980 (/ISS) P21980 (/ISS) |
Showing 1 to 10 of 76 entries
There are 37 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
7 | P00488 (/HDA) P21980 (/HDA) P21980 (/HDA) P21980 (/HDA) P21981 (/HDA) Q08189 (/HDA) Q8BH61 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | O95932 (/IDA) P49221 (/IDA) Q08188 (/IDA) Q6YCI4 (/IDA) Q8BM11 (/IDA) Q9WVJ6 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
6 | P21980 (/HDA) P21980 (/HDA) P21980 (/HDA) P22735 (/HDA) P49221 (/HDA) Q08188 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
5 | P21980 (/IDA) P21980 (/IDA) P21980 (/IDA) Q6P6R6 (/IDA) Q9WVJ6 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | Q08189 (/ISO) Q6YCI4 (/ISO) Q8BM11 (/ISO) Q8BZH1 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
4 | P22758 (/ISS) P23606 (/ISS) Q9GLK0 (/ISS) Q9JLF6 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | A6QP57 (/ISS) D4A5U3 (/ISS) Q08189 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P21980 (/IDA) P21980 (/IDA) P21980 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | P21980 (/HDA) P21980 (/HDA) P21980 (/HDA) |
|
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
|
3 | P21980 (/IDA) P21980 (/IDA) P21980 (/IDA) |
Showing 1 to 10 of 37 entries
