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CATH Superfamily 3.90.226.10

2-enoyl-CoA Hydratase; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
2-enoyl-CoA Hydratase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 40: Ethylmalonyl-CoA decarboxylase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ethylmalonyl-CoA decarboxylase. [EC: 4.1.1.94]
(S)-ethylmalonyl-CoA = butanoyl-CoA + CO(2).
  • The enzyme, which exists in all vertebrates, decarboxylates ethylmalonyl-CoA, a potentially toxic compound that is formed in low amounts by the activity of EC 6.4.1.2 and EC 6.4.1.3.
  • It prefers the S isomer, and can decarboxylate (R)-methylmalonyl-CoA with lower efficiency.
  • Cf. EC 4.1.1.41.
  • Formerly EC 4.1.1.n2.
 20 A0A1L8G8F1 A0A1L8G8F1 A0A2I2ZJM0 A0A2I2ZJM0 A0A2I2ZJM0 A0A2J8X8T9 A0A2J8X8T9 A0A2J8X8T9 F1NB38 F1R6N4
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(S)-methylmalonyl-CoA decarboxylase (sodium-transporting). [EC: 7.2.4.3]
(S)-methylmalonyl-CoA + Na(+)(Side 1) + H(+)(Side 2) = propanoyl-CoA + CO(2) + Na(+)(Side 2).
  • This bacterial enzyme couples the decarboxylation of (S)- methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na(+) across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.
  • It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
  • Formerly EC 4.1.1.41.
 20 A0A1L8G8F1 A0A1L8G8F1 A0A2I2ZJM0 A0A2I2ZJM0 A0A2I2ZJM0 A0A2J8X8T9 A0A2J8X8T9 A0A2J8X8T9 F1NB38 F1R6N4
(10 more...)
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