The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Protein tyrosine phosphatase superfamily
".
FunFam 65: Dual specificity protein phosphatase 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
15 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(5 more) |
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
14 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(4 more) |
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
14 |
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
(4 more) |
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
14 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(4 more) |
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
14 |
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
(4 more) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
14 |
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
P51452 (/IPI)
(4 more) |
MAP kinase phosphatase activity GO:0033549
Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate.
|
14 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(4 more) |
Showing 1 to 10 of 20 entries
There are 38 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
|
15 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(5 more) |
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
|
15 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(5 more) |
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
15 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(5 more) |
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
|
14 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(4 more) |
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
|
14 |
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
Q5RD73 (/ISS)
(4 more) |
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
14 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(4 more) |
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
14 |
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
P51452 (/ISS)
(4 more) |
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
|
14 |
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
P51452 (/IMP)
(4 more) |
Showing 1 to 10 of 38 entries
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
14 |
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
P51452 (/TAS)
(4 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
14 |
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
P51452 (/IDA)
(4 more) |
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
1 | Q9D7X3 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9D7X3 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9D7X3 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9D7X3 (/ISO) |
Showing 1 to 9 of 9 entries