The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Hect, E3 ligase catalytic domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1E3 ubiquitin-protein ligase NEDD4-likeE3 ubiquitin-protein ligaseE3 ubiquitin-protein ligaseE3 ubiquitin-protein ligase SMURF2E3 ubiquitin-protein ligase HUWE1 isoform X1E3 ubiquitin-protein ligase UPL1E3 ubiquitin-protein ligase HECW2 isoform X1E3 ubiquitin-protein ligase TRIP12 isoform X1Putative ubiquitin-protein ligase E3Aprobable E3 ubiquitin-protein ligase HERC4 isoform X1E3 ubiquitin-protein ligase UBR5 isoform X1E3 ubiquitin-protein ligase UPL7Apoptosis-resistant E3 ubiquitin protein ligase 1Putative Ubiquitin-protein ligase E3CE3 ubiquitin-protein ligase HERC2 isoform X2E3 ubiquitin-protein ligase UBR5 isoform X2Ubiquitin-protein ligase E3BE3 ubiquitin-protein ligase HECTD1 isoform X1E3 ubiquitin-protein ligase HACE1 isoform X1LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1E3 ubiquitin-protein ligase HECTD1 isoform X1probable E3 ubiquitin-protein ligase HECTD4 isoform X1probable E3 ubiquitin-protein ligase HECTD2 isoform X2E3 ubiquitin-protein ligasePutative E3 ubiquitin-protein ligase HECTD3E3 ubiquitin-protein ligase HACE1HECT and RLD domain containing E3 ubiquitin protein ligase 5HECT E3 ubiquitin ligaseCircadian trip, isoform CIQ and HECT domain proteinE3 ubiquitin-protein ligase TOM1E3 ubiquitin-protein ligase UPL5E3 ubiquitin-protein ligase hecd-1E3 ubiquitin-protein ligaseCircadian trip, isoform FE3 ubiquitin-protein ligase HECW2Apoptosis resistant E3 ubiquitin protein ligase 1Ubiquitin-protein ligase, putativeUbiquitin-protein ligase, putativeE3 ubiquitin-protein ligaseUbiquitin ligase (E3)E3 ubiquitin-protein ligase HECTD1E3 ubiquitin-protein ligase UPL1E3 ubiquitin-protein ligase Ufd4Ubiquitin ligase e3Hyperplastic disks-like proteinHECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1E3 ubiquitin-protein ligase UPL3G2/M phase-specific E3 ubiquitin-protein ligaseE3 ubiquitin-protein ligase hecd-1Ubiquitin protein ligase, putativeZn-finger_in_Ran_binding_protein_and_others/SPRY_domain/HECT-domain_(Ubiquitin-transferase)Ubiquitin protein ligase, putativeUbiquitin protein ligase, putativeUncharacterized protein, isoform AUbiquitin ligase, putativeHECT-domain (Ubiquitin-transferase), putativeUncharacterized proteinUncharacterized proteinUncharacterized proteinE3 ubiquitin-protein ligase hecw-1Predicted proteinPutative E3 ubiquitin-protein ligase HECTD4E3 ubiquitin-protein ligase HACE1HECT-domain ubiquitin--protein ligase E3E3 ubiquitin-protein ligase UBR5 isoform X1Uncharacterized proteinPutative E3 ubiquitin-protein ligase TRIP12-likeHECT E3 ubiquitin ligaseHect domain and RLD 3E3 ubiquitin-protein ligase hydUncharacterized proteinUncharacterized proteinPutative ubiquitin-protein ligase e3cUncharacterized proteinUBR E3 ubiquitin ligase homologUncharacterized proteinUbiquitin-protein ligase, putativeE3 ubiquitin-protein ligaseUncharacterized proteinUncharacterized proteinApoptosis-resistant E3 ubiquitin protein ligase 1Zn-finger in Ran binding protein and others/SPRY domain/HECT-domain (Ubiquitin-transferase), putativeUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinUncharacterized proteinUbiquitin-protein ligase, putativeE3 ubiquitin-protein ligasePredicted proteinPredicted proteinE3 ubiquitin-protein ligase UPL5Predicted proteinPredicted proteinUncharacterized proteinUncharacterized proteinE3 ubiquitin-protein ligasePredicted proteinProtein CBR-HECD-1Ubiquitin-protein ligase E3 CE3 ubiquitin-protein ligaseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized protein
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FunFam 49: G2/M phase-specific E3 ubiquitin-protein ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q7L622 (/IPI)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
1 Q5RJY2 (/IDA)
Showing 1 to 2 of 2 entries

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q5RJY2 (/IDA)
Blastocyst development GO:0001824
The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
1 Q5RJY2 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q5RJY2 (/IMP)
Showing 1 to 3 of 3 entries

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 F5GX24 (/IDA) G3V483 (/IDA) Q7L622 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 F5GX24 (/IDA) G3V483 (/IDA) Q7L622 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q5RJY2 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q5RJY2 (/ISO)
Showing 1 to 4 of 4 entries
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