The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
endopeptidase domain like (from Nostoc punctiforme)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: HRAS like suppressor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
13 P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53817 (/IDA) Q8R3U1 (/IDA) Q96KN8 (/IDA) Q9HDD0 (/IDA)
(3 more)
Phospholipase A1 activity GO:0008970
Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
13 P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53817 (/IDA) Q8R3U1 (/IDA) Q96KN8 (/IDA) Q9HDD0 (/IDA)
(3 more)
N-acyltransferase activity GO:0016410
Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
13 P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) Q4KLN5 (/IDA) Q96KN8 (/IDA) Q9CPX5 (/IDA) Q9HDD0 (/IDA)
(3 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P53816 (/IPI) P53816 (/IPI) P53816 (/IPI) P53816 (/IPI) P53816 (/IPI) P53816 (/IPI) Q9UL19 (/IPI)
N-acyltransferase activity GO:0016410
Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
4 P53817 (/ISS) Q5R611 (/ISS) Q8R3U1 (/ISS) Q9QZU4 (/ISS)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
3 Q8R3U1 (/ISO) Q9CPX5 (/ISO) Q9QZU4 (/ISO)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
3 Q5R611 (/ISS) Q9CPX5 (/ISS) Q9QZU4 (/ISS)
Phospholipase A1 activity GO:0008970
Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
3 Q8R3U1 (/ISO) Q9CPX5 (/ISO) Q9QZU4 (/ISO)
Phospholipase A1 activity GO:0008970
Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
3 Q5R611 (/ISS) Q9CPX5 (/ISS) Q9QZU4 (/ISS)
N-acyltransferase activity GO:0016410
Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
3 Q8R3U1 (/ISO) Q9CPX5 (/ISO) Q9QZU4 (/ISO)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
2 D2KX21 (/IDA) Q9QZU4 (/IDA)
O-acyltransferase activity GO:0008374
Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
2 Q9HDD0 (/IDA) Q9HDD0 (/IDA)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
1 Q9QZU4 (/ISO)
O-acyltransferase activity GO:0008374
Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
1 Q9QZU4 (/ISO)
O-acyltransferase activity GO:0008374
Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
1 Q9QZU4 (/ISS)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
N-acylphosphatidylethanolamine metabolic process GO:0070292
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
13 P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) Q4KLN5 (/IDA) Q96KN8 (/IDA) Q9CPX5 (/IDA) Q9HDD0 (/IDA)
(3 more)
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
8 P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53817 (/ISS) Q5R611 (/ISS)
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
8 P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53817 (/ISS) Q5R611 (/ISS)
Lipid catabolic process GO:0016042
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
8 P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53817 (/ISS) Q5R611 (/ISS)
Phosphatidylethanolamine acyl-chain remodeling GO:0036152
Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.
8 P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) Q9NWW9 (/TAS) Q9UL19 (/TAS)
Ether lipid metabolic process GO:0046485
The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
8 P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53817 (/ISS) Q5R611 (/ISS)
Regulation of adipose tissue development GO:1904177
Any process that modulates the frequency, rate or extent of adipose tissue development.
8 P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53817 (/ISS) Q5R611 (/ISS)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
7 P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) P53816 (/IDA) Q9UL19 (/IDA)
Phosphatidylinositol acyl-chain remodeling GO:0036149
Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains.
6 P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS)
Phosphatidylserine acyl-chain remodeling GO:0036150
Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains.
6 P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS)
Phosphatidylcholine acyl-chain remodeling GO:0036151
Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.
6 P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS)
N-acylphosphatidylethanolamine metabolic process GO:0070292
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
3 Q8R3U1 (/ISO) Q9CPX5 (/ISO) Q9QZU4 (/ISO)
N-acylphosphatidylethanolamine metabolic process GO:0070292
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
3 P53817 (/ISS) Q5R611 (/ISS) Q8R3U1 (/ISS)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
2 Q9HDD0 (/IDA) Q9HDD0 (/IDA)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
1 Q9QZU4 (/TAS)
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
1 Q8R3U1 (/IMP)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q8R3U1 (/ISO)
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
1 Q9QZU4 (/IDA)
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
1 Q8R3U1 (/IMP)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 Q9QZU4 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9UL19 (/TAS)
Phospholipid biosynthetic process GO:0008654
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q8R3U1 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q8R3U1 (/IEP)
Lipid catabolic process GO:0016042
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
1 Q8R3U1 (/IMP)
Positive regulation of keratinocyte differentiation GO:0045618
Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
1 Q9UL19 (/IMP)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 P53817 (/IMP)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 Q8R3U1 (/ISO)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
1 Q9QZU4 (/ISO)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
1 Q9QZU4 (/ISS)
Ether lipid metabolic process GO:0046485
The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
1 Q9QZU4 (/IDA)
Ether lipid metabolic process GO:0046485
The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
1 Q8R3U1 (/IMP)
Positive regulation of protein-glutamine gamma-glutamyltransferase activity GO:0150074
Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.
1 Q9UL19 (/IMP)
Regulation of adipose tissue development GO:1904177
Any process that modulates the frequency, rate or extent of adipose tissue development.
1 Q8R3U1 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
8 P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53816 (/ISS) P53817 (/ISS) Q5R611 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) P53816 (/TAS) Q9NWW9 (/TAS) Q9UL19 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P53817 (/IDA) Q9HDD0 (/IDA) Q9HDD0 (/IDA) Q9QZU4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9HDD0 (/IDA) Q9HDD0 (/IDA) Q9QZU4 (/IDA)
Nuclear envelope lumen GO:0005641
The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.
2 Q9HDD0 (/ISS) Q9HDD0 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8R3U1 (/ISO) Q9QZU4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9HDD0 (/ISS) Q9HDD0 (/ISS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q8R3U1 (/IDA) Q9QZU4 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P53817 (/IDA) Q9UL19 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9QZU4 (/ISO)
Nuclear envelope lumen GO:0005641
The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.
1 Q9QZU4 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q8R3U1 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8R3U1 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q8R3U1 (/IDA)
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